How to use mutation in a sentence

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Sentence Examples More generally, estimates of the average magnitude of epistasis per mutation pair are difficult to extract from designs of this type. The alb1 mutation is recessive and homozygous albino plants are white and die at the seedling stage. Mackenzie and her team followed that genetic trail to recreate the mutation in the lab. There is no known mutation of the virus to a state that would allow transmission between people. Geneticists have determined that taillessness occurred as the result of a spontaneous mutation. This suggests that the mutation might help explain both asymmetry and schizophrenia. The Y-axis shows the frequency of a prevalent mutation for each of the lines. Arrows indicate the position of the point mutation and the corresponding nucleotide on the wild-type sequence. Viruses basically clone themselves by various means, and due to replicative error reproduction, they have a high mutation rate. Resistance to antimicrobial agents enters microbial populations through mutation or immigration. It is genetically linked to an Italian variety called Primotivo, and possibly the first Zinfandel grapes were a mutation of this old world wine. If an individual inherits the mutation in both genes they will have sickle-cell disease. A post zygotic mutation restricted to somatic cells has been assumed to be responsible for most cases. In hypersensitive mutants the mutation synthetically enhances toxin lethality and can be functionally informative. We therefore employed a second assumption that autocorrelation of mutation rates occurs between insect genera, families, or suborders. Complementation analyses showed that each carried a mutation in a known male-specific lethal gene. Actually, the mutation has proved lethal in a protected environment as well. So tell me how a simple point mutation changes the information content of the gene. Genealogies can then be modeled using existing models of geographic subdivision, with mutation taking the place of migration. Whereas a translation error is like an inkblot marring one copy of a book, a mutation is a flaw in the printing plate, reproduced in every copy. Show More Sentences However, such covariant mutation can also occur within closely related groups. This frameshift mutation could be merely drifting to high frequency due to weak functional constraint. We estimate that reversion of the lac mutation is about one-tenth as likely as a null frameshift mutation in a typical gene. The 25-bp insertion causes a frameshift mutation and creates stop codons in all three reading frames. Many country sounds are so terrifying they could easily have come from the throat of a rabid bat mutation or a savage, cross-bred boar-wolf. We are studying properties of spontaneous mutation affecting quantitative traits of the annual crucifer, Arabidopsis thaliana. In this study, mutation analysis was used to analyze the association of hepatitis C and cryptogenic cirrhosis with hepatic iron concentration. In higher eukaryotes, impediments to repair can lead to high frequencies of mutation, cancer, and in some cases, cell or organismal death. Superficially it appears to be a periclinal chimera with a chlorophyll-deficient mutation in the second layer of the meristem. The structure of the database permits easy retrieval of specific mutation data for further analysis. A genetical analysis demonstrated that two mutations affect the mitochondrial genome whereas the third mutation is of nuclear origin. Because of some unknown quirk or mutation in the cosmic dance her genetic code did not enable her cells to make a full life possible. For each replicate, the first sweep of a beneficial mutation was identified using genetic markers. A clustered mutation means that two or more progeny of a family inherit the same mutation. Sickle cell anemia is caused by a mutation from a glutamate to a valine in the beta chain of the hemoglobin molecule. Several kinds of mutation may stabilize a protein, among them there is elimination of free sulfhydryl groups. Such sites may be indicative of hotspots of recombination or mutation or epistatic selection. Population structure can play an important role in determining the mean fitness of populations at equilibrium between mutation and selection. They studied a strain of mice with a gene mutation that causes them to have attacks of dyskinesia, or abnormal movements several times a day. The dashed curve is an exponential distribution with a mean equal to the average effect of a fixed mutation in the simulation. Show More Sentences The botanist who spots a double flower in a field of single sees a chance mutation that has altered that plant's genetics. We also analyze the evidence for the presence of a disease mutation after inferring the ancestry of a locus. Because these parameters span two orders of magnitude, we cannot determine mutation rates. No single mutation can produce a pentadactyl limb of vertebrate type on a Drosophila. A very small selective disadvantage would therefore require a much higher mutation rate to maintain genetic equilibrium. The plant and seed pigmentation components can be lost independently by mutation or unequal crossing over, leading to different derivatives. For biliary duct cancers, p53 gene mutation is an important contributor to carcinogenesis. Indeed, all but two haplotypes can be connected to other haplotypes by a single mutation. In almost all cancers, the cancer cells are found to have a mutation in one or more genes. The mutation rate was the same as that considered for the stationary populations. The proximity of the nonsense mutation to the start codon indicates that these mutations are null alleles. There are three types of mutations, the nasal mutation, the spirant mutation and lenition. In the case of strain 300, the mutation was a deletion of six contiguous base pairs of the nd1 sequence. Depending on the specific genetic mutation, she explains, the beast may have the head of a wolf or the bug-eyed visage of an ant. We can only estimate the relative expansion slippage rates and contraction slippage rates compared to the point mutation rate. The probability of producing a subsequent beneficial mutation will then also increase. In this example mutations accrue successively, starting with the most beneficial single mutation. For example, when a single favorable mutation arises and spreads, it carries with it any linked variants. The same pattern appears in tumor-associated genes undergoing either loss-of-function mutation or rearrangements. Second, mathematical geneticists showed that the gene frequency change by mutation is much smaller than the change by natural selection. Show More Sentences Cadmium compounds are inactive or weakly active in gene mutation and other genotoxicity assays. Only after the first several million generations has mutation added enough variability to reach the equilibrium. Perhaps the best demonstration of this comes from studies of mutation in reporter genes in transgenic mice. Throughout this section, we are concerned with the effective size for a single neutral locus without mutation. Dynamics of focus formation can be affected by mutation of genes involved in DNA metabolism. By the 60th cycle, the typical cell had four to five of the target genes inactivated by mutation. The gene mutation appears to work by restricting calorie absorption at the cellular level. In the absence of recombination and back mutation, the lost chromosome class cannot be regenerated. Damage caused to DNA may, in turn, induce mutation and chromosome abnormalities of the meristem cells. Singer notes well the various analogies between mutation and more prosaic political and cultural concerns. So it becomes clear that the solution to this problem is not in some political consciousness but in mutation of human consciousness. It commits the artist to a descent into time, into the processes of mutation, decay and dissolution. In a nutshell, it involves looking at a mutant line and mapping the mutation to a specific gene. For genetics and breeding, it is fundamentally important to know the germline mutation rate induced by a mutagen. The location of the mutation is indicated with the uppercase A in boldface type. Second, a mutation causing a switch in resource specialization allows one strain to sweep away its competitor. Recall that a twofold increase in secondary mutation frequency in recD was also seen for chromosomal loci. In silico strategies can be used to investigate the potential roles of a mutation on, for instance, protein stability. One theory is that the rate at which tumor cells die is too slow to keep pace with the rapid growth and mutation of tumors in the body. The fruits are misshapen and unnatural looking, a kind of elephantine mutation of, say, cherries. Show More Sentences Gene mutational damage in the liver can be assessed in the transgenic animal mutation assay. In one case, the mutation led to acquired torsade de pointes and ventricular fibrillation. As a cross-dressing, serially pierced, tattoo-laden celebrity athlete, he has set an X-Men-level standard for cultural mutation. To verify the mutation, researchers used the very latest gene sequencing techniques. The final verification of the mutation was ascertained by sequencing in both directions. However, such mutation must be considered in analysis of processes on longer timescales. We know now that the aberrantly low mutation frequency observed was caused by an inability to utilize lactose. Every known mutation has either decreased information content or was informationally neutral. Occasionally, however, a mutation occurs that allows fruit to develop from unfertilized female flowers, a process known as parthenocarpy. The mutation causes the brain cells to be oversensitive to neurotransmitters such as dopamine. Molecular access to the sda gene was via the sda HZ.P1 mutation by the method of plasmid rescue of genomic DNA flanking the transposon insertion. He discusses the mutation of punk's angry energy into something more thuggish and mindless. The mutation rate is measured as the number of nucleotide substitutions per site per generation. The gene that is responsible for the worms' mutation manufactures a small, stable strand of RNA that is not translated into a protein. When the mutation occurs in a cell, it essentially takes the brakes off the cell's growth, causing a malignancy. The mutation also reduced the copy number of the plasmids in otherwise wild-type strains. If that changes with a mutation or a recombination or reassortment of one virus to the other, that could change everything. It is now clear that mutation rates are greater in male than in female germ lines. This mutation also causes painful myotonic stiffness in humans. A less stringent criterion is whether a certain type of mutation occurs more often under conditions favorable to the survival of the resulting mutants. Show More Sentences Spatially variable selection adds substantial complication to the calculation of the probability of fixation of a new mutation in a structured population. For initial qualitative screening of elevated mutation frequencies in isolates, a single colony of each isolate to be tested was inoculated into 4 ml Luria broth. This distribution has to be integrated numerically to obtain its first two moments and the average values of the mutation load and inbreeding depression. To introduce a point mutation the gene must be cloned, the desired point mutation must be generated within that clone, and an I-SceI site must be inserted. A certain mutation has been shown to cause a completely red or yellow coat color in certain breeds such as Irish setters, yellow Labrador retrievers, and golden retrievers. In general, the high frequency of a null mutation may provide insights into the mode of selection as it relates to functional activity of a class of proteins. Using a virus they delivered a genetic mutation to the hearts of the hamsters that corrected a defect in the gene that regulates the way calcium is cycled through the heart. Cats with this mutation are known as polydactyls, or as Hemingway cats. Once multi-cellular eukarya developed, the increased scope for mutation drove an explosion in the diversity of eukarya about 600 million years ago. If the candidate mutation is involved in homeotic gene silencing, an increase in the numbers of sex comb teeth on the adult second and third legs is expected. Those with the disease have some cells that are genetically normal and some with the mutation. Thus, the polar bear's partly webbed feet may have come from a mutation which prevented the toes from dividing properly during its embryonic development. The period length of the double mutant strains was close to values predicted from assuming an additive or multiplicative effect from each mutation. If a deleterious mutation occurs, the chromosome carrying that mutation can be lost following unequal assortment during amitosis of the macronucleus. The solution to this mutation of complex growth is to go back to basics, to the old virtues we know, the respect for individual countries and their mores and manners. We checked in each of the 72 lineages whether the original mutation had reverted to its ancestral wild-type state by performing consensus population sequencing. The importance of target mutation in the development of new anti-infectives is illustrated by the most recent addition to the antibiotic arsenal, the oxazolidinones. But the baseball fans of Washington received their joyful, long-awaited wake-up call this week when the newest mutation of the team took the field in Florida. Together these three loci seem to fit the circumstances under which separate estimates of both mutation scalars and inheritance scalars can be obtained. Each candidate was then backcrossed to the unmutagenized parent and tetrads were dissected to ensure that the synthetic lethal phenotype resulted from a single mutation. Show More Sentences The Manx cats have either no tails or very short ones and are believed to have originated after a spontaneous mutation on the island hundreds of years ago. Here we describe a blond coat color mutation in the meadow vole that arose in a captive breeding colony established from wild-caught animals from southern Illinois. The spt6-140 mutation alters transcription and chromatin in our inverted repeats, as determined by Northern and micrococcal nuclease sensitivity analyses, respectively. In practice, the bacterial mutation test is the most widely used and best validated bioassay for assessment of potentially mutagenic contaminants. We illustrate our approach through application to data from a study of mutation induction in lacI transgenic mice after exposure to the flame retardant tris phosphate. Note that modeling mutation this way does not assume that it is equally likely to have a mutation arise that is beneficial overall vs. one that is deleterious. Classical genetics of human disease deals with monogenic disorders in which a single mutation in a single gene is causatively related to the phenotype. This was a mutation of a relationship that should, in theory, be unbreakably strong. If a mutation makes a single cell deaf to the needs of its body, it can develop into a tumor. The answer may be that the birther phenomenon is a mutation of a political virus called incoherence. This is just a mutation of the blood libel to suit modern politics. It was the launch on September 30 of the tabloid-shaped Independent that has been the catalyst for what surely amounts to a long-term newspaper industry mutation. Variation accumulates over time through a random process of mutation. Rather they evolved through a century-long process of mutation. They have been berated for being bland, boring, meandering and, most mystifying of all, not playing trance or whatever this week's essential dancefloor mutation is. The course of development can, however, be altered by mutation. As a matter of fact, the functions of books have undergone a process of mutation, and the underlying motivating force is now nothing but the soaring prices. He acknowledges his political mutation but says there was no epiphany. Random mutation is inevitable because mutation is a natural phenomenon. First, new mod variants can arise by mutation and spread by drift. Show More Sentences Genes can also be inactivated by mutation and subsequently deleted. The first is that this was a naturally occurring mutation in the Siamese. If scientists identify 100 individuals with the same mutation, and 75 of them have disease, the penetrance is 75 percent. Even if not every mutation leads to a new evolutionary pathway, the flies are a vivid example of one way mutation can provide variation for natural selection to work on. Some people have a genetic mutation that increases the amount of homocysteine their body produces so those people should probably switch to soy milk. Another nonsense mutation at codon 187 is shared by the human, the chimpanzee and the gorilla, so that it is most likely to have occurred in their ancestral species. Recessive suppressible Mutator alleles are usually caused by insertions in upstream regions, but interestingly, the tha1-m1 mutation is caused by a Mu1 insertion in an intron. One simple criterion for a developmental mutation is embryonic lethality, but this also catches mutations in genes involved in housekeeping functions. In this disease, which occurs when a child inherits from both parents a particular mutation in a single gene, bone marrow fails to produce enough blood components. How the mutation triggers lipodystrophy is not entirely clear, but this does suggest new therapeutic targets for individuals with the condition. Both observations raise the possibility that the virus may have become more neurotropic due to viral mutation and genetic drift. Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene. Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene that is inherited in an autosomal dominant pattern. The human Y chromosome is particularly exposed to high mutation rates due to the environment in which it is housed. Thus, the initial random vectors are all normalized and the childs are also normalized to unit vectors after any crossover or mutation operation. Many RNA interference and insertional mutation lines were used to knockdown or reduce the expression level of a defined 5-HT receptor. Consonant alternation is commonly known as consonant mutation or consonant gradation. A study discovered that a mutation in genes encoding both Neurokinin B as well as the Neurokinin B receptor can alter the timing of puberty. The study of fossils, on the other hand, can more specifically pinpoint when and in what organism a mutation first appeared. Recently a mutation in mtDNA has been used to help diagnose prostate cancer in patients with negative prostate biopsy. Show More Sentences They study processes such as mutation and gene transfer that drive evolution. Scientists believe a mutation caused the ancient trait to reassert itself as a form of atavism. Umlaut or mutation is an assimilatory process acting on vowels preceding a vowel or semivowel of a different vowel backness. Birdwatchers would enjoy a host of sparrows, a herd of swans, a descent of woodpeckers, a herd of wrens, and mutation of thrushes. An abundant form of noncoding DNA in humans are pseudogenes, which are copies of genes that have been disabled by mutation. A homozygous frameshift mutation in the mouse Flg gene facilitates enhanced percutaneous allergen priming. The biotechnological method of directed evolution has been applied to produce by mutation a large number of Penicillium strains. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. The Manx cat is a breed of cat noted for having a genetic mutation that causes it to have a shortened tail. Hence, in this model, most genetic changes in a population are the result of constant mutation pressure and genetic drift. The effect of a novel mutation detected at the splice site in 1 of the patients was predicted by the online in silico analysis software Fruitfly. Other studies support somatic gene mutation or partial gonadal dysgenesis as the responsible mechanism. In parasitic organisms, mutation bias leads to selection pressures as seen in Ehrlichia. Herein we present an FHL patient with a severe clinical course and a very rare perforin gene mutation. For example, to cross a temperature-sensitive mutation with an amber mutation, amber suppressor cells are infected at the low temperature. A unique clonal JAK2 mutation leading to constitutive signaling causes polycythaemia vera. The GSTP1 polymorphism was determined by a tetra-primer amplification refractory mutation system PCR as described in an earlier study. But when selection is weak, mutation bias towards loss of function can affect evolution. Mechanisms that can lead to changes in allele frequencies include natural selection, genetic drift, genetic hitchhiking, mutation and gene flow. I've studied three-letter organisms which by point mutation saltate into others, as yam into ram. Show More Sentences Paramyotonia congenita with an SCN4A mutation affecting cardiac repolarization. Introduction of stop codon and consistent inheritance of the mutation with the disorder indicated its pathogenic nature. For example, in systemic mastocytosis, the KIT mutation may not be reliably detected if there are insufficient numbers of mast cells. Pathogenetic aspects of the A8344G mutation of mitochondrial DNA associated with MERRF syndrome and multiple symmetric lipomas. The mutant strains have a shrinker phenotype which is caused by a mutation in GARA receptors. A familial mutation renders atrial natriuretic peptide resistant to proteolytic degradation. The genetic study conducted identified a pathogenic change C698G, a missense mutation in FH gene. This causes a missense mutation in which a G-C pair is replaced by an A-T pair after replication. Atrial natriuretic peptide frameshift mutation in familial atrial fibrillation. Experts say they have no idea why the red king crab is blue but suspect it's a genetic mutation. Guv, we've 'ad a call that there's a shelf-stacker down at Tesco who used a soft mutation when everyone knows 'e should have done a nasal. The results shed light on molecular processes such as mutation and recombination in humans, the scientists report in the July 20 Cell. Genetic analysis showed homozygotic S53N mutation on MVK gene 3rd exon, and the HIDS diagnosis was made. In 2002, Bazan and colleagues reported that KRAS mutation in codon 12 might be involved in the regulation of mucins. If a mutation occurs within a gene, the new allele may affect the trait that the gene controls, altering the phenotype of the organism. The new treatment is actually disproportionately applicative to non-smokers, as it only targets one type of genetic mutation. The pair have the disease''s G551D mutation, and have to take up to 50 tablets a day and endure frequent nebuliser and physiotherapy sessions. Beta-thalassernia due to a novel nonsense mutation at codon 37 found in an Afghanistani family. Unsatisfied free radicals can spur the mutation of cells they encounter and are, thus, causes of cancer. They found one-a mutation of a single gene, which seems to be responsible for the majority of short-legged dogs' stumpiness. Show More Sentences This mutation encodes an enzyme, Bcr-Abl tyrosine kinase, that causes white blood cells to proliferate. Wheat with this mutation was harvested more frequently and became the seed for the next crop. The most promising therapeutic approaches are nonsense mutation read-through and antisense oligonucleotide-induced exon skipping. A novel nonsense mutation in the LPL gene in a Chinese Neonate with Hypertriglyceridemia. This change was possible because of a random mutation in the wild populations at the beginning of wheat's cultivation. The capsular gene clusters were sequenced entirely, and a missense mutation within synD was identified. This tolerance to PPD was thought to be cosegregated with the starch mutation, and is not a pleiotropic effect of the latter. The researchers are also tweaking their system to tether glutamate to normal receptors without a cysteine mutation, notes Trauner. Systemic mastocytosis is characterized by a somatic mutation of the KIT protooncogene. Approximately 25 per cent of all MTC cases are genetic in nature, caused by a mutation in the RET proto-oncogene. Consequently, they preserve a genetic record from individual to individual that is altered only through mutation. A single positively selected West Nile viral mutation confers increased virogenesis in American crows. In addition, more archaic pronouns and forms of mutation may be observed in Literary Welsh. Thus, although a male may have a well adapted Y chromosome free of excessive mutation, it may never make it in to the next gene pool. In alpha thalassemia, at least one of the alpha globin genes has a mutation or abnormality. These two conditions combined put the Y chromosome at a greater risk of mutation than the rest of the genome. Gln170ter mutation is known to cause termination of translation just after helix 3 of NK homeodomain, thereby deleting the COOH-terminal NK domain. That is, the mutation underlying Timothy syndrome causes shrinkage, rather than growth, of the wiring needed for the development of neural circuits that underlie cognition. Microsatellites are nuclear-encoded, codominant markers that have characteristically high mutation rates and, hence, a high degree of allelic variation. Therefore, without realizing, early farmers selected for this mutation. Show More Sentences A simple method for detection and analysis of carcinogenic nitrofuran compounds and their metabolites by combining chromatography and spot mutation tests. Glaciers forced the early human populations who had originally migrated from northeast Siberia into refugia, reshaping their genetic variation by mutation and drift. One in 20 Amish people has a mutation that destroys a gene, APOC3, involved in triglyceride metabolism, as compared with one in 150 Americans generally. For Beijing genotype strains, the increase in mutation frequency during exposure to RIF could be due to described missense mutations in the mut genes. The regional distribution of this mutation among European populations indicates that it originated in Southern Scandinavia and spread with Viking expansion. Over and above mutation analysis, genealogical studies can be very useful in populations where there are common founder effects and church records. The large, lumpy variety of tomato, a mutation from a smoother, smaller fruit, originated in Mesoamerica, and may be the direct ancestor of some modern cultivated tomatoes. Autosomal dominant polycystic kidney disease results from a mutation in PKD1 or PKD2 causing cysts in the kidney and often leading to end-stage renal disease. As was the case with our patient, long-duration travel and hyperthermal balneotherapy are possible environmental triggers for PFMS patients with the V726A mutation. Bioinformatics tools were used to confirm this, and to determine the probable pathogenicity of the novel missense mutation in exon 7 and the 5'UTR sequence change. Another study on population genetics of the mutation showed that during the Neolithic period, FVL in Europe had probably expanded from Turkey, Anatolia. In the first study, scientists have discovered that one major consequence of the C9orf72 gene mutation is disruption of RNA export from the cell nucleus. Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts. The team identified the gene affected by the mutation code for asparagine synthetase, the enzyme responsible for synthesising the amino acid asparagine. Instead, he describes evolutionary processes as analogous to a blind watchmaker in that reproduction, mutation, and selection are unguided by any designer. A confrontation and mutation of two foods, mortadella and pamplemousse. It's still unknown whether the mutation improves the plants' cereal productivity as well as leaf production, and how reduction of ethylene affects other plant functions. The third variant, a compound mutation found in a French family and associated with familial hypobetalipoproteinemia, exhibits a dominant negative effect on PCSK9 secretion. The mutation rate of this virus is well modeled by a molecular clock. A team of researchers has identified the genetic mutation that causes Proteus syndrome, a rare disorder in which tissue and bone grows massively out of proportion. Show More Sentences Despite the constant introduction of new variation through mutation and gene flow, most of the genome of a species is identical in all individuals of that species. Better estimates of mutation rates in these viruses are needed. For example, if a mutation is deemed to have occurred 30,000 years ago, then this mutation should be found amongst all populations that diverged after this date. Goldberg, identify optimal solutions by simulated reproduction and mutation of a population of solutions defined by an initial probability distribution. Although both mutation rates and average fitness effects of mutations are dependent on the organism, a majority of mutations in humans are slightly deleterious. Female smokers in particular are susceptible to emphysema because of a mutation in a gene that helps repair damaged chromosomes, a new study has shown. Evaluation of thrombophilia disorders established the patient to be heterozygous for methylenetetrahydrofolatereductase C677T gene mutation as the only finding. Other reports indicated that mutation in the above chromosome regions resulted in human preaxial polydactyly, mouse Hx, Hm and Ssq limb abnormality, and chicken polydactyly. Factor Leiden mutation which causes genetic predisposition to thrombophilia was found to be negative and MTHFR mutation was found to be heterozygously positive. When a patient has such a mutation, he or she manufactures a defective version of the protein homogentisate dioxygenase and, thus, suffers from alkaptonuria. However, her original reference obtains this number for the relative mutation rates in male and female germ lines for the lineage leading to humans. Because rifamycin drugs are widely used to treat TB, the difference in the mutation frequencies of Beijing and EAI genotype strains for RIF is a major finding. In genetic HLH, a mutation occurs in one of the proteins responsible for intracellular vesicle docking and release of preformed proapoptotic granzyme and perforin. Severe clinical symptoms in patients with the M694V mutation may be attributed to increased levels of acute-phase reactant seven during the attack-free period. Non-isotopic RNase cleavage assay for mutation detection in MEFV, the gene responsible for familial Mediterranean fever, in a cohort of Greek patients. Mutation prevention is essential to prohibit a bacterium from developing resistance to antibiotics to which it is exposed. Mutation is the primary source of genetic variation upon which natural selection can act. Mutation and overexpression of labial result in altered homeotic gene expression in the tritocerebrum. Mutation in the myostatin 3'UTR have been found at the molecular or cellular level in a recent study by Clop et al. Mutation in bone morphogenetic protein receptor-IB is associated with increased ovulation rate in Booroola Merino ewes. Show More Sentences A GENETIC MUTATION RESPONSIBLE FOR GLYCOGEN STORAGE disease type Ilia has been identified in Inuit in northern Quebec by a team of Canadian and Japanese researchers. Examples from Classical Literature Here we seem to have a plain statement of the origin of new forms by mutation. To read of a noble deed brought swift tears to her eyes in these days of mutation, and stirred her to emulative dreams. We are never surprised to find that an ordinary upright plant produces as a sport or mutation a pendulous, or fastigiate form. There is no trace of such vocalic mutation in Gothic, our most archaic Germanic language. Voice mutation is not one continuous period of growth of vocal bands and laryngeal cartilages. In some ways, genetic mutation acquires the status of a new means for synthesizing new plants and animals, and even new materials. The same remark holds good in the case of the nasal mutation of the tenues. As a rule the medial mutation of the tenues and mediae is not denoted in O. Welsh. Apart from every thing else, it was a mournful witness to the world's mutation. The phenomenon of mutation is not confined to animals in a state of domestication. Mice with a mutation in the Engrailed 2 gene also have a smaller cerebellum. Ask nothing of men, and, in the endless mutation, thou only firm column must presently appear the upholder of all that surrounds thee. A new eye-color mutation in drosophila and its mode of inheritance. People with an inherited mutation of a gene called alpha-B crystallin can suffer progressive heart failure, but nobody has known why. Time is, therefore, not a factor in the mutation of species. A rough-hewn resemblance is first brought about by a process of mutation. The situation is not symmetrical because the mutation is not complete. There is nothing corresponding to this consonantal mutation in Goidelic. Because collagen makes up the fibrils that anchor the two skin layers together, Uitto's team concludes that dominant dystrophic EB results from the collagen mutation. Munt should be the first to discover the misfortune was not remarkable, for she was so interested in the flats, that she watched their every mutation with unwearying care. Show More Sentences Food and Drug Administration has approved the cobas EGFR Mutation Test v2 for companion diagnostic use. Find more words! 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What is the opposite of mutation? Words that rhyme with mutation What is the plural of mutation? What is the adverb for mutation? What is the adjective for mutation? What is the noun for mutation? Translations for mutation Use our Sentence Generator Nearby Words mutating mutates mutated mutate mutants mutant mutational mutations mutatis mutandis mutative mutator mutch 8-letter Words Starting With m mu mut muta mutat mutati mutatio