How to use mutants in a sentence

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Sentence Examples This indicated that these mutants had point mutations and not exon deletion or insertion. The ten mutants were grouped into nine categories, on the basis of thermotolerance characteristics. Can such mutants be identified in the genetic screens presently in use, or is there a need for improved or even novel screens? Viral mutants that are not neutralised by antibodies induced by the available vaccines have been detected. Second, the enzymatic activity for the active site mutants was determined in vitro. Mutant studies are limited by the availability of suitable mutants and the ability to generate and screen for them. Let me explain that there are bad mutants and good mutants, just like real people. From a study of the behaviour of certain mutants, the general molecular nature of the genetic code had been deduced. This study also demonstrated that the escape mutants may show lesser fitness. The remaining five mutants were shown not to be allelic to any of the genes already known. New approaches using mutants or transgenic plants have not led to more conclusive results. The authors are not aware of mutants with similar phenotypes in the vicinity of these mapped regions. In this paper, a novel screen is described for mutants hypersensitive to gamma radiation. The role of the latter in starch biosynthesis is unknown as no mutants have been identified to date. Similar arguments and requirements apply to mutants created by transposon mutagenesis. Among several mutations rumoured to alter senescence are the clavata mutants. It did not reduce the world to rubble, or morph the human race into radiated mutants. Like the photoreceptor mutants they all showed a response comparable to the wild type. From this screen, 13 wpch mutants were recovered with reduced somatic mosaicism and low germline reversion rates. Two new viviparous mutants showed some signs of precocious germination but did not emerge fully on the cob. Show More Sentences On the contrary, the surgically-treated plants and the sterile mutants put more into their reproductive structures and live longer. These mutants lacked normal conidiophores and phialides and formed rod-shaped, catenated cells directly from hyphae. Many of these mutants had clear structural abnormalities, for example, different colored eyes. The plants were grown in vitro on MS medium supplemented with ammonium succinate in the case of the Nia 30 mutants. The evolution of homeotic mutants, according to Simpson, still depended on selection acting on populations of individuals. Several of these articles dealt with mutants affecting synapsis, meiosis, or disjunction. These phenotypic classes are discussed below, with reference to previously identified zebrafish melanocyte mutants. These are the properties expected of mutants lacking an enzyme that cleaves joint molecules. In our groundnut breeding program, two phenotypically identical mutants were isolated. One out of three putative double mutants that were transferred to soil developed a fasciated stem and a structure similar to an aerial rosette. In addition, rates of light-limited photosynthesis and oxygen yield are decreased in the mutants. The screen was performed in duplicate and repeated twice, and mutants common to both screens were characterized further. However, survival curves for all the mutants showed some upward concavity, which would be consistent with a resistant subpopulation of cells. We now know that the latter situation is conducive to the emergence of resistant mutants. We determined the dissociation constants of our mutants for skeletal muscle actin using capped filaments. Double mutants showing a growth defect were scored as candidate interactants. Many semidwarf mutants have pleiotropic effects on traits other than culm length. Many mutants died or showed pleiotropic defects casting doubt on the specificity of their retinal phenotype and were not included in this report. In addition, fission yeast mutants deficient in the enzymes that attach Ned8p, or in the ned8 gene itself, are inviable. This mutant displayed involute leaves and early flowering, although less than clf and icu2 mutants. Show More Sentences Both mutants have a significantly enlarged 60S peak relative to isogenic wild-type cells. Large-scale over-expression and purification of the mutants resulted in comparable quantities of isolatable enzymes. The displacement of the ventral nerve cord coincided with that of body wall muscles in mutants. As expected, this group included heme-deficient mutants and flocculent isolates, which were disregarded. Other mutants displayed green fluorescence or lacked fluorescent properties. A number of mutants showing abnormalities in courtship behavior have been identified, many of which show reduced levels of courtship behavior. Obviously, a movie that features futuristic technology and mutants with spectacular powers is going to be heavy with special effects. The separation of the buds may reflect an additional bud neck defect or the completion of cytokinesis in these mutants. Some of the new mutants are special, even if many of them feel generically characterized. From a screen of 24,000 mutagenized flies, 17 mutants with presynaptic defects in synaptic transmission were recovered. A genetic selection for mutants that activate this pathway uncovered a class of mutants defective in cell wall integrity. We constructed deletion mutants for nonessential genes by one-step gene replacements. As much as possible, mutants were vegetatively propagated to prevent loss of each genotype. The behaviour of pigment metabolism mutants is consistent with a similar function for chlorophyll as a protein protectant in vivo. Eleven mutants whose decline in viability was fully or partly suppressed by depolymerizing the spindle were retained. Ven mutants exhibit gross anatomical defects in the nerve cords, including their complete detachment from the body wall. Small colony mutants 540 and a subclone of 540 were obtained from cells exposed to pyrimethamine. Second, the rate of encapsidation of deleterious mutants may be increased during co-infection. We checked all of the mutants for phenotypes that might indicate defects in endocytosis by other cell types. Most hermaphroditic mutants were phenotypically similar with a mature gynoecium composed of five carpels and 10 stamens. Show More Sentences The dosage compensation complex cannot accumulate on the male X chromosome in the mutants. Other aberrant gametophyte phenotypes were observed among the group of mutants that could form antheridia. Moreover, we did not observe increased levels of seed or ovule abortion in any seth mutants. All the respiratory-deficient mutants previously isolated in our laboratory have been induced by treatment with acriflavine or ethidium bromide. Those magnificent mutants return for an action-packed sequel that knocks spots off the original movie and leaves you itching for more. Although both mutants were isolated, each is morphologically distinct, suggesting adventitious genetic alterations. This is inferred because spore viability is reduced in some checkpoint single mutants of budding yeast. Most of the multiple alleles were found as rare mutants not in a collection but in landraces from Hokkaido island. A similar pattern was observed for young lateral roots with stronger signals in the mutants that extended beyond the root tip. These residual responses could reflect leakiness of the mutants, redundant olfactory mechanisms, or some kind of nonspecific odorant response. In hypersensitive mutants the mutation synthetically enhances toxin lethality and can be functionally informative. We selected for mutants that were resistant to the anthelmintic drug levamisole. Such mutants have been generated by chemical mutagenesis, gene disruption, and antisense gene silencing. In contrast to hair follicles of nonaffected littermates, the follicles of mutants were curved and twisted randomly, thus producing wavy hair. The enzyme, hen egg lysozyme, has not been shown to form fibrils in vivo, and only mutants have been associated with amyloid-related diseases. Both of these mutants seem to be thiamin auxotrophs because they appeared normal when grown on media supplemented with 0.1 mM thiamin. Mutant frequencies were calculated by dividing the median number of mutants by the average number of total cells. The genotypes of all double mutants were confirmed by backcrosses to wild type. These mutants were then screened for their ability to suppress other yme1 phenotypes, as well as for inherent collateral phenotypes. The suo mutations were screened for their ability to restore growth of pex2 mutants on OA medium. Show More Sentences There was no significant difference in grain number per ear observed in unstressed plants of mutants. Bacteria that have lost the ability to colonize are called symbiosis mutants. With different mutants a correlation between the total amount of synthesized carotenoids and photosynthetic oxygen evolution was observed. For comparison, we sequenced genomic DNA from the stock used to generate the mutants. Amino acid analysis and metabolome studies of the mutants are now in progress. Both biosynthetic and transferase enzyme activities of GS are affected in the mutants. This finding implied that the mutants are defective in heme-oxygenase, an enzyme that converts heme into biliverdin. In contrast, later formed leaves remained smaller and total leaf biomass remained substantially reduced in the mutants. However, fewer hormone biosynthesis or action mutants are known which exhibit greater than normal growth. In many cases, these mutants are characterized with regard to phenotype, physiology and molecular biology. Museums and private collectors have for centuries preserved specimens of monsters and mutants. In these mutants, the meiotic products remain in interphase in unfertilized eggs and undergo inappropriate DNA replication. We also isolated several mutants that produce unfertilized eggs or show an early arrest in embryonic development. Historically, three programmes for the identification of photorespiratory mutants in chemically mutagenized seed sets were performed. To see why the Philly mutants are causing such confusion, some vaccine science is in order. No mutants had significant numbers of asci with more than four spores. It occurred via the selection of suitable variants, often natural mutants. For nicotinate hydroxylase assays, cnxE strains were first crossed to a mutant in the structural gene encoding xanthine dehydrogenase to generate cnxE hxA1 double mutants. In addition to testing the generality of fungal survival factors, auxotrophic mutants allow several key aspects of fungal biology to be assessed in vivo. Morphological mutants were grouped in a class with yellow conidia and other with pale vinaceous conidia as opposed to the green wild type conidia. Show More Sentences Another anion, azide, is used in the study of bacteriorhodopsin mutants as a substitute for proton donor or acceptor when they are altered in the protein. Of the 230 mutants, 55 fell into the first class and we continued the characterization of 36 of these mutants that had highly penetrant mutant phenotypes. This is most likely to be a problem for mutants with a mitotic phenotype. Homozygous mutants were obtained by intercrosses of the heterozygotes. The phh1 single mutant is not completely sterile but is nearly sterile, whereas the msa1 deletion mutants conjugated efficiently even in nutrient-rich medium. Evidence of a carotenoid mutant of rice was suggested by the phenotype of several mutants for which viviparous seeds germinated into albino seedlings. First, there are spontaneous mutants, oddballs that arise by chance. The resulting plasmids were conjugated into the respective mutants of M. extorquens and the transconjugants tested for the ability to grow on methanol. A large number of genes have been described and assigned to specific locations among the 12 chromosomes, and numerous monogenic mutants are available. Whether the functionally independent mutants are the result of mutations in a single bifunctional gene or two separate genes has not been determined. Harvested bacterial colonies containing mutant plasmids were grown in LB medium in the presence of ampicillin and kanamycin to maintain the selective pressure on the mutants. Almost all mutants were found to behave as simple Mendelian recessives. Imagining novels as biological specimens creates a crazed and mythic zoology of hybrids, beasts, mutants, and aberrations. We reasoned that if programmed cell death influences organismal death, mutants defective in apoptosis should have abnormal, possibly extended, life spans. Thirty-four monosomes and telosomes, representing 18 of the 26 chromosomes, were used in combination with six mutants that were associated with nine loci. Thus, two of the polymerase mutants are modest spontaneous mutators for some point mutations in yeast strains that are proficient in DNA mismatch repair. But if we're destined to spend the next several years watching movies about mutants, musclemen and assorted other misfits, it'd be nice if those movies were good. In addition to the family of cannibalistic mutilators, there is a whole bunch of weird-looking people in the basement, doing medical experiments on mutants. Several of these mutants are insensitive to gibberellic acid. Based on sequence similarity to known wax biosynthetic genes, mutants with potentially altered cuticle properties can be selected from this collection. Show More Sentences A less stringent criterion is whether a certain type of mutation occurs more often under conditions favorable to the survival of the resulting mutants. The 10 resistant mutants were outcrossed twice to wild type. After the initial discovery, the mutants were crossed inter se and pure homozygous stock of the mutant was established. Such mutants that cannot heptamerize have been shown to be more effective antigens. Compared to controls, larval EcR mutants were hyposensitive to both thermal and mechanical stimulation. Rick Tomato Genetics Resource Center at UC Davis is a gene bank of wild relatives, monogenic mutants and miscellaneous genetic stocks of tomato. Importantly, overexpression of WASP in trc mutants and transheterozygotes of trc and Tsc2 suppressed their synaptic overgrowth phenotypes. Its small genome, rapid life cycle, small size, and large number of mutants and genomic resources make it an ideal angiosperm for plant research. Standing in hisway are telepath Charles Xavier, shape-shifter Raven Darkholme and five gifted mutants. Yeast that made the aromatic compounds were transported around the plate four times as often as the scentless mutants were. Isogenic autosomes to be appliedin optimal screening for novel mutants with viable phenotypes in Drosophil melanogaster. Until 2000, most extended spectrum beta-lactamines were mutants of classical TEM and SHV plasmid-mediated penicillinases. Urease-null and hydrogenasenull phenotypes of a phylloplane bacterium reveal altered nickel metabolism in two soybean mutants. Magneto predictably uses the development to agitate fellow rebel mutants, saying the vaccine is nothing short of a government-mandated genocide. Using missense mutants to test the ability of Hsp60 and Hsp70 chaperones to rescue misfolded proteins. Quite implausibly, April's late father was the scientist who created these mutants. But this time, Krrish is up against a super villain called Kaal and his team of mutants. One of the main difficulties faced in practice is due to the large number of mutants that can be generated for a program under test. Aided by telepath Charles Xavier, shape-shifter Raven Darkholme and five gifted mutants, Erik must stop Shaw, who intends to spark nuclear war. They found that the mutant flies raised with the younger control flies lived twice as long as mutants housed with other mutants. Show More Sentences Based on this complex gene regulation it is hypothesized that flhD and fliA mutants will have pleiotropic phenotypes. They then created a line of Drosophila mutants completely lacking both forms. The X-Files definitely wasn't all mutants and little green men. So it is with the X-Men, and this stunning followup has the X-led good mutants having to team up with Magneto's villains to defeat Brian Cox's evil military scientist. Mouse mutants will be used to study the in vivo role of catalytic activity of piwi proteins in piRNA biogenesis and identify putative targets by transcriptomics approaches. However, there is no report describing polymorphisms of GnRHR gene in teleosts, and few studies about the relationship between mutants and reproductive traits. The researchers discovered one set of mutants that fit the bill. Meanwhile, in the X-Men movies Patrick Stewart and Hugh Jackman have been marshaling their superpowers against Ian McKellen's axis of evil mutants. Double ambers revert at 10-8-10-9, and therefore, reversion is negligible. Double-amber mutants are made by crossing single-amber mutants with each other. Analyses of double phosphodeficient mutants proved that the availability of even one out of three phosphorylation sites is sufficient for the feedback monomerization to occur. These included dark coloured flower, light coloured flower, albous flower, pink flower, red flower, small flower, biflorate and triflorate mutants. During one skirmish, cannon-fire breaks the stone seal, unleashing hordes of mutants which swarm the globe, dragging victims into the machine to swell enemy ranks. Strigolactones are produced by the non-mycorrhizal plant Arabidopsis thaliana, and plant mutants defective for strigolactone production have not yet been obtained. In the Marvelverse, mutants are potential victims of hate crimes and of state-sponsored pogroms, and of the sort of bureaucratic prying that is often a prelude to the latter. Examples from Classical Literature These non-luminous mutants occasionally give rise to atavistic brilliantly luminous forms. Meanwhile, Sebastian Shaw plots to plunge the world into war with the help of mutants Riptide, Azazel and Emma Frost. These, like the mutants in drosophila, are fully equipped at the start. Find more words! 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What is the opposite of mutants? Words that rhyme with mutants What is the adverb for mutants? What is the adjective for mutants? What is the noun for mutants? Use our Sentence Generator Nearby Words mutant mutandis mutagens mutagenicity mutagenic mutagenesis mutate mutated mutates mutating mutation mutational 7-letter Words Starting With m mu mut muta mutan mutant