| Pain receptors in the tissues, called the nociceptors, send electrical impulses to the brain signaling pain messages. |
| These substances stimulate the nociceptors at the related area and lead to local sensitivity. |
| Fish, like humans, have nociceptors which detect painful stimuli that respond to chemicals, heat and pressure. |
| The transduction of noxious stimuli begins with peripheral nociceptors. |
| These actions are attributed to binding with nociceptors, which causes a period of enhanced sensitivity followed by a refractory period of reduced sensitivity. |
| Most C-fibres are polymodal, while some only become active under inflammatory conditions and are referred to as 'silent' or 'sleeping' nociceptors. |
