| Fish, like humans, have nociceptors which detect painful stimuli that respond to chemicals, heat and pressure. |
| The transduction of noxious stimuli begins with peripheral nociceptors. |
| These substances stimulate the nociceptors at the related area and lead to local sensitivity. |
| Most C-fibres are polymodal, while some only become active under inflammatory conditions and are referred to as 'silent' or 'sleeping' nociceptors. |
| The skin also has pain receptors called nociceptors Pain is a subjective perception of an unpleasant sensation which originates in a specific region of the body. |
| Technically known as 8-methyl-N-vanillyl-trans-6-nonenamide, it works by triggering nociceptors — the body's pain sensors — creating a sensation of intense heat. |
