| These mediators lower the nociceptor threshold, making the receptors more responsive to painful stimuli. |
| Once stimulated, nociceptors fife action potentials that travel along the nociceptor fibre to the dorsal horn of the spinal cord. |
| At the extremes, there can be both nociceptor activation without pain or pain without receptor activation. |
| When they killed off a certain population of nociceptor neurons, the mice stopped responding to being poked, but still responded to heat. |
| Nociceptor stimulation triggers action potentials in sensory nerve fibres that transmit impulses to the dorsal horn of the spinal cord. |
| Whether the drugs work or not, the specter of addiction is very real, as is the potential for irreversible changes in nociceptor pathways within the central nervous system. |
