| These mediators lower the nociceptor threshold, making the receptors more responsive to painful stimuli. |
| At the extremes, there can be both nociceptor activation without pain or pain without receptor activation. |
| When they killed off a certain population of nociceptor neurons, the mice stopped responding to being poked, but still responded to heat. |
| Whether the drugs work or not, the specter of addiction is very real, as is the potential for irreversible changes in nociceptor pathways within the central nervous system. |
| Pain sensation begins with the stimulation of a nociceptor, or nerve ending, and resultant activation of a sensory nerve. |
| The source of pain determines the type of nociceptor involved. |
