| The FRET measurements also show a slow increase in oligomerization of EGFR monomers after growth factor binding. |
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| In mouse pituitary gonadotrope cells, MMP2 and MMP9 can mediate EGFR transactivation. |
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| These injurious substances have been reported to activate EGFR through direct ligand-mediated activation, or via transactivation. |
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| Other tissue treatments should be avoided in specimens destined for EGFR testing. |
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| Oncogenic mutations in genes encoding key downstream effectors within the EGFR signalling pathways may also be responsible for resistance to EGFR-targeted MoAbs. |
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| Several novel chemotherapeutics that target specific signaling pathways are now available as anti-cancer agents including EGFR inhibitors and rapamycin. |
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| Primary objectives of the study include evaluating concordance between urinary circulating tumor DNA, blood ctDNA, and tumor tissue for determining EGFR mutational status. |
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