“During latent infection, the viral genome persists as an episome, and viral gene expression is highly restricted.”

“Whenever an infected cell divides, the episome makes a copy of itself, and each daughter cell receives one.”

“Interestingly, overexpression of the functional wild-type HA-Mcm7p from an episome or an integrated allele was toxic for normal cell growth and viability.”

“Lieberman and his colleagues found that the three telomeric proteins might help Epstein-Barr virus episomes persist in cells.”

“Protein binding protects sites on stable episomes and in the chromosome from de novo methylation.”

“The molecular basis for this persistence is largely unknown, but 2 recent studies have given evidence in support of persistent circular HBoV episomes.”