| Gene mutational damage in the liver can be assessed in the transgenic animal mutation assay. |
|
| At the level of populations, the scaling of mutational effects with pleiotropy can be addressed via the neutral theory of molecular evolution. |
|
| This analysis suggested that the African population is close to equilibrium between mutational forces and genetic drift. |
|
| If this occurs frequently, then MA experiments will be practically useless for studying any properties of mutational covariance. |
|
| The distribution of mutational effects was assumed to be gamma, which allows a wide variety of shapes. |
|
| Transferred genes are subject to those mutational processes affecting the recipient genome. |
|
| But in some other genetic realms we do differ widely, for example, mutational load — the number of mutations we carry. |
|
| The estimate is based on a large mutational target, the 804-base TMV MP gene that encodes the viral movement protein, which is a cognate sequence for the viral replicase. |
|
| Most importantly, if mutations have no effect on organismal fitness, the genealogy of a sample can be separated entirely from the mutational process. |
|
| In the case of simian virus 40, mutational analysis showed that the consecutive thymine nucleotides play an essential role in replication initiation. |
|
| The argument that a mutational change would make the avian flu virus a much greater threat is seriously flawed. |
|
| Cancer is caused by mutational damage to genes that otherwise hold a cell's reproductive cycle in check, and thus stop that cell proliferating. |
|
| Some researchers have suggested that the frequency of these mutations could represent a founder effect rather than mutational hot spots. |
|
| When a new branching in a tree is discovered, some phylogenetic names will change, but by definition all mutational names will remain the same. |
|
| Additionally, the high copy number per cell, low recombination rate, high mutational rate, and dominantly maternal heritance have made the mitochondrial genome a powerful tool for evolutionary studies. |
|
| A fortiori, for Behe, evolution of large, complex creatures with smaller populations and longer generations will fail, starved of mutational raw materials. |
|
| Fluticasone propionate did not induce gene mutation in prokaryotic microbial cells, and there was no evidence of toxicity or gene mutational activity in eukaryotic Chinese hamster cells in vitro. |
|
| The researchers concluded that mutational testing is needed in people who do not respond to imatinib or who lose their hematologic or cytogenetic response during treatment. |
|
| Bacteria have mechanisms for mutational genetic change to antimicrobial resistance, as well as ways to transfer this resistance among unrelated bacteria. |
|
| The numbers of participating individuals and the times available are such that widespread exploration of the mutational space has often been possible, leaving the main selective decision to environmental conditions. |
|
|
|
| Michel Morange: The richness and rootedness of this concept lie in the combination of three aspects: functional unit, mutational unit and recombination unit. |
|
| Developmental or mutational biases have also been observed in morphological evolution. |
|
| The Company uses its proprietary gene knock-out technology to create a mutational gene library in the zebrafish for research to support its internal drug development program. |
|
| Primary objectives of the study include evaluating concordance between urinary circulating tumor DNA, blood ctDNA, and tumor tissue for determining EGFR mutational status. |
|
| Mutational specificity of chromium compounds in the hprt locus of chinese hamster ovary-K1 cells. |
|
