| When they treated cells with mitomycin C, which promotes DNA cross-linking, that protein, then known as KIAA1018, gathered at damage sites. |
| Chemicals such as mitomycin C and the nitrogen mustards generate inter-strand cross-links, while cisplatin is associated with intra-strand cross-links. |
| On the other hand, other antitumor drugs such as trabectedin, lurbinectedin and mitomycin C bind to the minor groove. |
| Combined treated with morphine and mitomycin C produced a significantly higher frequency of micronucleated binuclear cells than mitomycin C alone. |
| Other groups also have reported good results with mitomycin, vinblastine, and cisplatin, although the regimen produced excessive toxicity in some series. |
| Intraoperative application of mitomycin C is very effective but there are concerns as to the long-term effects of this treatment on keratocyte and endothelial cell density. |
