“Exposed skin sites that exhibit erythema can be clearly delineated from unexposed skin by sharp boundaries.”

“First, the scalp is examined for evidence of erythema, scaling, or inflammation.”

“These reactions include large areas of erythema and extensive lymphadenopathy or lymphadenitis.”

“Later, the skin becomes ichthyotic with large plate-like scales and variable erythroderma.”

“Affected children present with severe blistering and ichthyotic erythroderma soon after birth.”

“Observation of lipid vacuoles in neutrophils in peripheral blood smears in patients with ichthyosiform erythroderma is diagnostic.”