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What is a twist of fate?

What is a twist of fate? Here are some definitions.

Noun
  1. (idiomatic) An unfortunate turn of events.
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Examples
But in a terrible twist of fate, the disease she has worked so hard to find a cure for has now come to haunt her.
The newly formed friendship is severely tested and I won't give the ending away, but it is indeed an astonishing twist of fate for all three men.
And in a serendipitous twist of fate, he is now in a position to offer my band discounted studio time at a local recording studio.
A calendrical twist of fate found us celebrating Christmas this year on the middle day of December.
By an ironic twist of fate, each of the four sides in the hat must face up to a derby match on the deciding Saturday.
Perhaps, but it'll more likely be the law of averages, a destiny thing, a twist of fate.

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