| This guideline is considered to be applicable to the total of aldicarb and its toxic metabolites, aldicarb sulphoxide and aldicarb sulphone. |
| The two major metabolites of aldicarb, the sulphoxide and the sulphone, are also acetyl-cholinesterase inhibitors, with the sulphoxide approximately equipotent with the parent compound and the sulphone somewhat less potent. |
| Ingested aldicarb sulphoxide and aldicarb sulphone are metabolized in the same manner as the parent compound. |
| The sulphone, desmethylthioether and mercapturic acid conjugate minor metabolites were observed at lower levels. |
| The normal degradation of the sulphoxide to the sulphone is not affected. |
| Aldicarb and its by-products, aldicarb sulphoxide and aldicarb sulphone, inhibit acetyl-cholinesterase in the nervous system. |
