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What is a penetralium?

What is a penetralium? Here are some definitions.

Noun
  1. the innermost (or most secret) part of a building; an inner sanctum
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Examples
It is because there are nerval poles in the lips, as there are elsewhere, connected, telegraphically, through nerves, to the very penetralium of soul itself.
To say nothing of its never failing positive pronouncement upon the nature and pathological significance of morbid growths which are visible en masse to the naked eye, it can plunge into the very penetralium of structural organization.
I had no desire to aggravate his impatience, previous to inspecting his penetralium.
Coleridge, for instance, would let go by a fine isolated verisimilitude caught from the penetralium of mystery, from being incapable of remaining content with half-knowledge.
It is, at any rate, the immediate penetralium in which the mystery that is still the aspiration, if not the reproach, of physiological science lies concealed.

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