The drugs in the latter complexes are covalently connected by a peptide linker, whereas those associated with the oligonucleotide duplexes are chemically independent species. |
Close to the sphere surface, the oligonucleotide interacts with the evanescent field of the WGM, which extends about a wavelength into the buffer solution. |
The latter is conjugated to primer oligonucleotides that are pre-annealed to a complementary circular oligonucleotide. |
The quaternary nitrogen atom in lycobetaine plays an important role in the formation of hydrogen bonds between the compound and the oligonucleotide. |
Creation and purification of the double-labeled oligonucleotide is synthetically demanding. |
This comprises length alterations of oligonucleotide repeat sequences that occur somatically in human tumours. |