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What does irritation mean?

Looking for the meaning or definition of the word irritation? Here's what it means.

Noun
  1. The act of irritating or annoying
  2. The state of being irritated
  3. The act of exciting, or the condition of being excited to action, by stimulation; -- as, the condition of an organ of sense, when its nerve is affected by some external body; especially, the act of exciting muscle fibers to contraction, by artificial stimulation; as, the irritation of a motor nerve by electricity; also, the condition of a muscle and nerve, under such stimulation.
  4. A condition of morbid excitability or oversensitiveness of an organ or part of the body; a state in which the application of ordinary stimuli produces pain or excessive or vitiated action.
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They both reduce the acidity of stomach juices, which reduces irritation of the stomach, duodenum, and esophagus.
In an elegant book, these parallel universes are the sole source of irritation.
The most common adverse effects reported related to skin irritation and skin burning.
The rash appears because part of the immune system is overly sensitive to irritation.
Onset of action is rapid and side effects include local irritation and unpleasant taste.
Excessive breathing of fumes causes headache, weariness, and irritation of the nose and throat.

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