| However, after several backcrosses, its heterozygotes could be distinguished from the dominant homozygotes. |
| Clinical and biochemical study of a family with three homozygotes. |
| Homozygotes and heterozygotes at individual sites were distinguished by their chromatographic patterns. |
| For example, in inbred populations there may be very few heterozygotes but several different homozygotes. |
| Similarly, inbreeding decreases the effective size of selection but unmasks deleterious alleles in homozygotes. |
| Here, the founder effect causes rapid speciation after an increase in inbreeding increases selection on homozygotes, leading to rapid genetic change. |
