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What is a fly in the ointment?

What is a fly in the ointment? Here are some definitions.

Noun
  1. (idiomatic) Something which ruins or spoils everything else; a nuisance or problem; an unpleasant or disagreeable detail.
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Examples
This evening, I would like, at the outset, to point out a fly in the ointment.
The only fly in the ointment today was Gentle Annie, a nasty hill.
Yes, don't you know I'm going to throw a fly in the ointment?
There is still, however, one fly in the ointment, and that is the relatively non-binding nature of this directive.
The fly in the ointment for the Democrats, as reflected in this poll, is that they still don't have a candidate.
There is, of course, one fly in the ointment, and that is the fact that space exploration costs money.

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