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What does exasperation mean?

Looking for the meaning or definition of the word exasperation? Here's what it means.

Noun
  1. The act of exasperating or the state of being exasperated; irritation; keen or bitter anger.
  2. Increase of violence or malignity; aggravation; exacerbation.
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Examples
After her initial exasperation, she'd seemed to settle into a mood of placidness.
Finally, the detective sighed in exasperation, and ordered his partner to take the teacher away, cuffing his hands from behind.
Despite the exclamation mark, he talks in the flat, imperturbable vowels of Sussex, his voice rising not so much in volume as in exasperation.
The doctor tried to reason with me but finally gave up with a look of exasperation.
In exasperation, Hoxsey attempted an end run by approaching the National Cancer Institute.
There was also a half hour of exasperation when I temporarily mislaid my handheld somewhere in the hospital.

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