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What are callouses?

What are callouses? Here are some definitions.

Noun
  1. plural of callous
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Examples
He acquired a row of callouses on each hand and a chronic ache in his back, but beyond that he did not accomplish very much.
This can lead to blisters, corns, and callouses, and can even contribute to bunion formation.
On my word the good wife and mother hasn't the kinks out of her fingers yet, nor the callouses from her hands, by Jove!
His hair was greasy and stringy, and his skin had developed brown callouses.
But the world, which veils the spirit and callouses the instincts, makes curiosity for most people the criterion of interest.
He felt her callouses grind and grate on his, and a great wave of pity welled over him.

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