| The only regular manufacturers of butalbital in the last decade were Denmark, Germany and the United States. |
| The substances amobarbital, cyclobarbital and pentobarbital were scheduled in 1971 when the 1971 Convention was adopted, while butalbital was added in 1987 to Schedule III of the 1971 Convention. |
| Other notable recommendations include: ยท Don't use opioid or butalbital treatment for migraine except as a last resort. |
| Butalbital has been used for the manufacture of a number of preparations exempted in the United States from certain control measures, in accordance with article 3 of the 1971 Convention. |
| Denmark has been the leading exporter of butalbital. |
| In recent years, the manufacture of butalbital in the United States has been fluctuating, falling sharply from 40 tons in 2002 to 5.4 tons in 2003 and accounting for a little over half of total output in the past two years. |
