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What does anaplastic mean?

Looking for the meaning or definition of the word anaplastic? Here's what it means.

Adjective
  1. (oncology) Of, or relating to, a tumor that shows little histogenetic differentiation. It implies that a tumor is high grade and likely to behave in an aggressive fashion.
  2. (surgery) Of or relating to plastic surgery.
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Examples
Xalkori blocks the growth of tumours caused by a mutant form of the gene which encodes a signalling molecule known as anaplastic lymphoma kinase.
In their article, 4 of 5 cases were found to have villous or tubulovillous adenomas adjacent to the highly anaplastic carcinomas but with no obvious transition.
Of the 14 anaplastic oligoastrocytomas, 6 were designated astrocytoma predominant and 2 were oligodendroglioma predominant.
Finally, a highly anaplastic growth can occur, in which the cancerous cells bear no visible relation to the parent tissue.
We defined advanced stage as nodal or metastatic spread and high grade as poorly differentiated, undifferentiated, or anaplastic disease.
He was discussing a possible link between the implants and anaplastic large-cell lymphoma or ALCL, a cancer that involves the immune system.

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