| Trichlorfon use is broadly based on its action as an inhibitor of acetylcholine esterase. |
| Carbosulfan is extremely toxic to mammals and its toxicity is mediated through inhibition of acetylcholine esterase, a respiratory enzyme. |
| Depolarization of the presynaptic membrane causes release of acetylcholine into the synaptic cleft. |
| All nerve agents act by inhibiting the enzyme acetylcholinesterase, which breaks down the neurotransmitter acetylcholine. |
| Instead the acetylcholine accumulates and affects both voluntary an involuntary muscles. |
| In patients with chronic hypoxemic lung disease, polycythemia has been shown to impair the vasodilator response to acetylcholine. |
