| Causes and effects The structure of thalidomide is similar to that of the DNA purine bases adenine and guanine. |
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| Taking even a single dose of thalidomide during early pregnancy may cause major birth defects. |
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| But in 1998 the FDA approved thalidomide for treating the debilitating and disfiguring lesions associated with erythema nodosum leprosum. |
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| Most folks who know about drug discovery will tell you about the lessons of thalidomide as they relate to the chirality of drugs. |
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| Studies have shown that administration of thalidomide improves weight gain in both HIV-positive and HIV-negative tuberculosis patients. |
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| Cases of phocomelia in the early 1960's in Germany and Australia led to the identification of thalidomide as a human teratogen. |
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| Kevin is one of the many people born with shortened limbs after his mother took thalidomide to treat morning sickness during pregnancy. |
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| The patients were randomly assigned to either 200 mg daily of thalidomide or a dummy drug for a period of 24 weeks. |
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| Approximately 5,000 to 7,000 malformed infants were born to women who ingested thalidomide during pregnancy. |
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| Though these uses aren't approved by the FDA, doctors can prescribe thalidomide for other indications, sometimes called off-label uses. |
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| At latest follow-up, the patient was still on clonidine, metoprolol, nifedipine, cyclophosphamide, prednisone, and thalidomide. |
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| Between 1957 and the early 1960s, thalidomide was used by several thousand pregnant women across the world to ease their morning sickness. |
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| Medications like thalidomide or isotretinon can cause tragic birth defects. |
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| In multiple myeloma patients, the risk of renal dysfunction may be increased when pamidronate disodium is used in combination with thalidomide. |
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| The patient was treated with thalidomide 400 mg daily for 10 weeks. |
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| Their mothers had been prescribed thalidomide, a sleeping pill, to combat the effects of morning sickness during pregnancy. |
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| In addition, thalidomide also appears to have an effect on the immune system. |
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| Scientists have discovered that thalidomide can inhibit the formation of new blood vessels. |
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| However thalidomide therapy can have side effects that not infrequently force the treatment to be broken off. |
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| The drug thalidomide was licensed in the 1950s to help expectant mothers deal with morning sickness. |
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| He came to Strasbourg, France, to witness the free speech argument in Harry Evans's landmark thalidomide case. |
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| The same of course has happened with thalidomide and the causation of phocomelia in human embryos. |
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| Each step in this chain of events is potentially sensitive to thalidomide intercalation. |
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| In cases such as thalidomide and traffic accidents, compensation is paid that acknowledges the foetus as distinct from the mother. |
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| We do know that thalidomide was declared safe until children were born without limbs. |
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| In the case of thalidomide, Celgene's CANTAP programme provides the drug free of charge to those who qualify for financial reasons. |
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| Mr. Speaker, I am old enough to remember the disaster caused by thalidomide, for example. |
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| Last week, La Presse reported that the majority of thalidomide victims had yet to receive any compensation. |
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| Some of the autistic children born to mothers who took thalidomide also had misshapen ears, as well as abnormalities in the nerves of the head and face. |
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| This was in spite of such FDA victories as the ban of thalidomide, which caused phocomelia in more than 8000 babies in Europe, where the drug was freely used. |
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| We propose that thalidomide can be an alternative or combination antipruritic treatment for patients who do not obtain enough relief from conservative therapy. |
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| It also appears to be more common in children affected by thalidomide than in the general population, although there is nothing specific about their squints. |
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| If thalidomide intercalates into guanine residues of DNA and interferes with integrin beta 3 synthesis, where would such intercalation have its greatest impact? |
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| In AIDS patients, in addition to treating cachexia, thalidomide was also useful in treating lesions of the mouth and throat, and early tests indicated that the drug may inhibit the replication of the AIDS virus. |
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| Let us remember also the thalidomide and silicone breast implant problems. |
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| Thirty years later, thalidomide emerged as a potential treatment for Kaposi's sarcoma, a rare skin cancer whose purple blotches are the bane of many HIV patients. |
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| The Patented Medicine Prices Review Board says it will review pricing of the cancer drug thalidomide, also known by the brand name Thalomid, after its price jumped by more than 900 per cent. |
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| There are the tragic circumstances with thalidomide. |
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| For thalidomide, the consideration of these factors can only be addressed by the manufacturer as the decision to seek approval for a drug product is made independently of Health Canada. |
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| The drug thalidomide caused many birth defects and led to an iatroepidemic. |
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| As a result, DNA intercalators may be carcinogens, and in the case of thalidomide, a teratogen. |
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| In fact, phocomelia, the most common limb malformation associated with thalidomide has existed throughout history and continues to manifest itself to this day. |
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| The ongoing repurposing of the infamous drug thalidomide may include treatment of Crohn's disease, an incurable bowel condition. |
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| In the 1990s thalidomide was found to be effective in treating cachexia, the severe weight loss that occurs in patients with diseases such as AIDS, tuberculosis, and leprosy. |
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| In this case, a four-limb-deficient thalidomide woman with numerous health problems was imprisoned in a cell with facilities unadapted to meet her specific needs. |
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| What is Health Canada doing to help give Canadians access to thalidomide? |
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| That drug was called thalidomide and the disorder was called phocomelia. |
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| They refused to accept mounting evidence that thalidomide was responsible for a sudden outbreak of a rare birth defect called phocomelia, in which children are born with severely deformed internal organs or limbs. |
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| Another possibility is a teratogen, which is a birth defect-inducing toxicant along the lines of thalidomide. |
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| In case reports, case series, and open-label trials, thalidomide significantly reduced pruritus associated with conditions such as actinic prurigo and paraneoplastic pruritus. |
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| Mat was born with congenital phocomelia, caused by exposure to the drug thalidomide. |
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| In the late 1950s and early 1960s up and down Britain, mothers who had taken thalidomide, a drug to prevent morning sickness, gave birth to babies with shocking deformities. |
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| Quantitative measurement of thalidomide by gas-liquid chromatography. |
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| In the late 50s and early 60s up and down Britain, mothers who had taken thalidomide, a drug to prevent morning sickness, gave birth to babies with shocking deformities. |
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| Therefore, whenever symptoms arise in patients with multiple myeloma who are receiving thalidomide, extramedullary plasmacytomas should be considered. |
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| One of the most unfortunate and best known examples of this was the mild sedative and anti-emetic Thalidomide. |
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| Thalidomide may also play a role in treating arthritis-related conditions, such as ankylosing spondylitis, Still's disease and Sjogren's syndrome. |
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