Once in the lung, the spore circles up into a spherule, defined by a chitinous cell wall and filled with a hundred or so baby endospores. |
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When the spherule is sufficiently full, it ruptures, releasing the endospores and stimulating an acute inflammatory response that disrupts blood flow to the tissue and can lead to necrosis. |
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The initial spherule forms a growing skin of polymer with the most active catalyst sites on the outside. |
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Immunity to coccidioidomycosis induced in mice by purified spherule, arthrospore, and mycelial vaccines. |
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Evaluation of the protective efficacy of the killed Coccidioides immitis spherule vaccine in humans. |
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Once inside people or animals, they transform into the spherule form recognized in biopsy specimens. |
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Ultimately the spherules rupture and release the endospores, each of which has the ability to develop into a mature spherule, propagating the cycle. |
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The process starts by tailor-making a porous spherule of PP in a reaction process similar to Himont's Catalloy technology, then grafting various monomers. |
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