| Normal diploid human cells multiply for a finite number of generations and then enter a state of replicative senescence. |
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| They possess a replicative mode of transposition, so that the insertions are mostly stable. |
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| But most healthy mammalian cells managed just a few dozen divisions before they stopped, a process known as replicative senescence. |
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| In normal somatic cells, the telomeres shorten with replicative age, and telomerase is not detected. |
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| Viruses basically clone themselves by various means, and due to replicative error reproduction, they have a high mutation rate. |
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| At the back of your mind is the idea that a lightning flash triggered a replicative system in the primordial soup, and suddenly the show was on the road. |
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| In germinal lineages, replicative insertions are frequent, occurring in premeiotic, meiotic, and postmeiotic cells, while excision events are rare. |
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| Alterations of proteasome function have been recorded in various biological phenomena including ageing and replicative senescence. |
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| This study demonstrates that a random approach reduced the replicative fitness of CHIKV in both primate and arthropod cells. |
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| We have a unique panel of cells from all stages of OSCC development, some which undergo replicative senescence and others which are immortal. |
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| When telomeres reach critically shortened length and a DNA damage signal is induced, a replicative senescence, or cell ageing, occurs. |
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| So this is a combined vaccine called a chimera, combining the yellow fever replicative machinery and the dengue surface proteins. |
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| Instead the nRNA product contains several short oligonucleotide sequences that are mirror images to unique sites on the viral mRNA from the viral replicative genes. |
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| Moreover, the complete replicative cycle of the virus remains un-decoded. |
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| Human diploid fibroblasts cultured under normal conditions have been reported to develop an irreversible cell cycle arrest, referred to as replicative senescence. |
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| Replicative DNA polymerases are very accurate enzymes with error rates usually in the range of 10-5 per replicated nucleotide. |
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