How to use nucleic in a sentence

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Sentence Examples The most widely used method for separation of nucleic acids is precipitation with ethanol or other organic solvents. A virus is a small packet of infectious nucleic acid material surrounded by a protein coat. The extracted nucleic acid was suspended in TE and treated with RNase at 37 deg C for 30 min. This advanced nucleic acid amplification test is rapidly gaining importance in diagnostic microbiology. Quality control was performed to ensure the tissue specimens contained sufficient quantity of nucleic acids for amplification testing. Three internal calibrators and total plasma nucleic acids are extracted simultaneously with test samples in each set of testing. Transfection is a process whereby nucleic acid, primarily as recombinant DNA of known sequence and functionality, is placed in a target cell. Transport of polyelectrolytes, in particular of nucleic acid fragments, through proteinaceous pores in membranes has also been reported. The concentration of protein and nucleic acids in extracts and the molecular weight of DNA were subsequently determined. Uric acid, formed from nucleic acids, is reabsorbed from filtrate by active transport, and a small portion is actively secreted into the urine. Hydrogen bonding also plays an important role in determining the three-dimensional structures adopted by proteins and nucleic acids. We select this level of quasi-rigidity at 0.23 following a previous investigation of the dynamics of double helical nucleic acid oligomers. The functions of these non-coding nucleic acid sequences are only partly understood. The unmodified biopolymers may be nucleic acids, polypeptides, proteins, carbohydrates, lipids and analogues thereof. Material was spun at 6000 rpm for 1 min to pellet nucleic acid, and supernatant was removed to a clean tube. However, reactive oxygen species generated by UVA radiation, particularly singlet oxygen, can also damage nucleic acids. The primary categories for natural polymers include polysaccharides, proteins, nucleic acids, and polyisoprenes. There are two types of nucleic acids, DNA and RNA, both of which are suitable for the transfer of information. Proteins are polymers of amino acids, while nucleic acids are polymers of nucleotides. The cell uses a related nucleic acid called RNA to construct a working copy of that strand. Show More Sentences The viral load or the amount of nucleic acid present can be tracked over time using a graphical patient report. Because nucleic acids always carry a negative charge, separation of nucleic acids occurs strictly by molecular size. The C5 atom of cytidine bears a substantially larger negative charge than many nitrogen atoms in popular nucleic acid force fields. Let us remember that they are concerned with a DNA endonuclease, so I had some experience dealing with an enzyme that cut nucleic acids. We have modeled the closing kinetics and in so doing have obtained stacking enthalpies and entropies for single-stranded nucleic acids. Nevertheless, the most optimal method for extracting nucleic acid must also be determined for each specimen type. Amino acids are the compounds of which proteins are made, and nitrogen bases are one of the building blocks of nucleic acids such as DNA and RNA. The nitrogen bases in the nucleic acids are joined via sugar linkages to long chains of alternating sugar and phosphate. Unlike larger polypeptides and proteins, small nucleic acid duplexes and hairpins do not have a dense core to which this effect would apply. Nucleotide or nucleic acid is made from glucose and is used in the food industry to add flavour to foods. These instruments also have built-in fluorimeters that detect fluorescence emitted from nucleic probes annealed to target DNA at the conclusion of each PCR cycle. However, studies have shown that native DNA might actually be the cross-reacting antigen whereas modified nucleic acid polymers stimulate antibody response. But nucleic acid vaccination crosses an important demarcation line in that it altogether avoids introducing infectious organisms into the body. The calculations of Sponar suggest the nonplanarity of amino groups that are bound to aromatic systems such as in aniline or in the nucleic acid bases. In the case of UVBs, their energy makes them particularly absorbable by the nucleic acids of the epidermis, and hence by the DNA of those cells. The accelerating pace of nucleic acid sequencing allows scientists to read any organism's complete genetic code. The new test, known as nucleic acid testing, directly measures the viruses' RNA, their genetic material. The blood was then tested again with the more sophisticated nucleic acid assay. He was visiting Columbia to see how a fan might convert nucleic acid into digital songs. He then hopes to integrate a replicating nucleic acid system with dividing protocells. Show More Sentences In general more than one copy of the introduced nucleic acid may occur in the new organism. It involves the direct insertion of the nucleic acid package using a ballistic method. The nucleic acid test for the aids virus was introduced by Héma-Québec about two months ago. We also expanded our line of nucleic acid testing products in the Asia Pacific with approval of the Procleix Ultrio test in China. Viruses of these two families are icosahedrons and contain nucleic acids with limited genetic information. Lysogenic phages incorporate their nucleic acid into the chromosome of the host cell and replicate with it as a unit without destroying the cell. Detection of viral nucleic acid in patient specimens has been demonstrated to improve enteroviral detection. A composition comprising an aerosolized mixture comprising a cationic lipid complexed with a nucleic acid. Use of lanthanum or scandium ion to amplify nucleic acid polymerase activity and optionally also to inhibit nuclease activity. The use of Paecilomyces lilacinus strains which excrete nucleases for breaking down nucleic acids. Ideally suited to characterize protein and nucleic acid secondary and tertiary structure. Some epoxide forms can bind to proteins and nucleic acids and potentially lead to genotoxicity. A purified and isolated nucleic acid molecule encoding a transferrin receptor protein of a strain of Moraxella. In this infectious form, viruses are simply a central core of nucleic acid surrounded by a protein coat called a capsid. Promising advances have been made on a number of diagnostic technologies, such as dipstick-type immunoassays and nucleic acid tests. Organotherapy has a direct effect on stimulating the function of the organ by enhancing the selection of enzymes and specific nucleic acids lacking in the organ. The maps detail the genetic sequencing of the nucleic acids, or nucleotides, in the virus. But some of his ingredients, like the nucleotide building blocks of nucleic acids, are quite complex. His ambition was to discover the enzymes that made RNA and DNA, which are polymers, or chains of nucleic acids. The practical and technical limitation of the DNA probe technique is that it requires the presence of nucleic acids in the sample. Show More Sentences Nitrates are the main source of nitrogen for plants and an essential constituent for nucleic acids and amino acids. Folate plays an important role in the metabolism of nucleic acids and amino acids. In addition, once nucleic acids have been extracted for PCR, another test can be made to detect Clavibacter michiganensis subsp. According to the available evidence, these particles can pass directly through the cell membranes and therefore may attack the nucleic acids. Dr Wang's starting point is the redundancy of the genetic code used by nucleic acids. Yet nestling amid the quarks and transistors and the nucleic acids and nanotubes, there is a question. When yeast nucleic acid is treated with dilute alkali it is split into components, each of which is made up of one molecule each of phosphoric acid, sugar, and nitrogenous base. The polymerase chain reaction assay, branched DNA assay and nucleic acid sequence-based amplification assay quantitate human immunodeficiency virus RNA levels. Therefore, as the tissue is processed as a mass, a nucleic acid-based approach usually involves contamination by nonmalignant and nonviable cancer cells. Enzymes that act on substrates such as polypeptides, nucleic acids, oligosaccharides, or lipid membranes often interact with more than one substrate molecule. Enzyme immunoassays for detecting chlamydial antigen and direct nucleic acid probe assays are the most widely used tests and can evaluate large numbers of samples. However, as mammalian cells will not readily take up naked nucleic acids, the RNAs have to be complexed with agents such as cationic lipids to allow them to enter the cells. At least six different combination approaches are under active development, including chemical combination and vector technologies using vaccinia, polio, Salmonella, BCG and nucleic acid immunization. This is the first book to provide a comprehensive overview of the field of artificial nucleic acids. However, when they hybridise to a nucleic acid strand containing a target sequence they undergo a conformational change that enables them to fluoresce. Folates of the vitamin B family play an important role in the metabolism of amino and nucleic acids. Nucleoside, a structural subunit of nucleic acids, the heredity-controlling components of all living cells, consisting of a molecule of sugar linked to a nitrogen-containing organic ring compound. You know – proteins, nucleic acids, carbohydrates, lipids. Each of the nucleic acids and the proteins increases an expression level under salt stress. Cellular content of granuloma was measured by assaying activity of N-acetyl glucosaminidase and total nucleic acid content. Show More Sentences Phosphorus is a constituent of nucleic acids, phospholipids, phosphoproteins, phosphate esters, dinucleotides and adenosiue triphosphate. A method for inhibiting the heat denaturation of a nucleic acid duplex, comprising the step of contacting a nucleic acid duplex with a composition which comprises a ubiquitin-like protein. An isolated, purified or recombinant nucleic acid sequence encoding a gibberellin 2-oxidase enzyme which comprises a nucleic acid sequence as shown in Figure 1, Figure 5 or Figure 7, or its complementary strand. The substance, first named nuclein because it seemed to come from cell nuclei, became known as nucleic acid after 1874, when Miescher separated it into protein and acid components. A method for obtaining a lyophilized composition containing nucleic acids, characterized in that it comprises lyophilizing an aqueous solution of nucleic acids in the presence of disaccharides and collagen. Peptide Nucleic Acids are non-ionic nucleic acid analogues capable of sequence specific binding to complementary RNA or DNA with high affinity, and are resistant to nucleases and proteases. A variation on the theme of synthetic DNA entails the synthesis of nucleic acids that carry the natural base pairs of DNA but possess a backbone made with sugars other than deoxyribose. To comprehend complex biological processes you must also understand the structure, function and reactions of nucleic acids. It might seem at first that quantifying anagenesis for proteins and nucleic acids would be impossible, because it would require comparison of molecules from organisms that lived in the past with those from living organisms. This database contains infrared spectra of a variety of biochemicals such as peptides, amino acids, carbohydrates, nucleic acids, sugars, lipids, steroids, terpenes, alkaloids, glycosides, carotenoids, flavonoids, etc. However, the RDA method with a cloning step requires at least 1 week for the determination of the nucleic acid sequence. Qiagen's acquisition of Operon is highly synergistic with Qiagen's existing nucleic acid separation and purification activities. Nonenveloped viruses presumably undergo a similar process, by which the protein capsid is degraded, releasing the naked viral nucleic acid into the cytoplasm. The report segments the global nucleic acids isolation and purification market by technology, application, product, end user, and geography. The mechanism of action of epirubicin, although not completely elucidated, appears to be related to its ability to bind to nucleic acids by intercalation of the planar anthracycline nucleus with the DNA double helix. Nucleosides are the building blocks of nucleic acids, but also perform other functions within organisms not related to genetics at all. The labeled nucleic acid probes hybridize specifically to the amplicon. Currently, DNA sequencers, nucleic acid amplification and electrophoreis account for the largest percentage of sales among bioinstrumentation. If nucleic acids containing the novel combination of genetic material are not present in a product, there can be no risk of transfer of a genetic modification to another organism. Mercuriation of nucleic acids is performed after ISH is completed using haptens with SH groups that bing the mercury. Show More Sentences Health Canada has approved a new nucleic acid test from Roche Diagnostics to screen donated blood for HIV-1 Group M RNA, hepatitis C RNA and hepatitis B DNA in a single, automated assay. It is based upon the direct amplification and detection of viral nucleic acids rather than antibody production by the immune system of the infected person. The ability to use the first fully automated nucleic acid test for West Nile virus will enable blood centers, clinics and hospitals in Canada to reliably detect the virus, often in people who are not yet showing symptoms. What I can tell you is that, in and of itself, the nucleic acid test for HIV is certainly not sufficient reason to sign a death warrant on that question which is currently on the form. They have found that isoproterenol can inhibit glycation, a series of reactions where sugars damage proteins, nucleic acids and lipids, and is one of the major causes of cataract. We expect this technology to have applications in the fields of oncology and immunology and to facilitate delivery of proteins, peptides and nucleic acids. The nucleic acid molecules are made up of sequences of nucleotides. Target amplification assays are based on the ability of complementary oligonucleotide primers to specifically anneal and allow enzymatic amplification of the target nucleic acid strands. Prof. Göbel asked Dr Wielgosz to comment on the possible role of the BIPM in the area of bioscience, and in particular on whether the BIPM should become involved in the measurement of proteins and nucleic acids. All but three of the codons correspond to particular amino acids, and the order of the codons in the nucleic acid corresponds to the order of the amino acids in the protein. Recently, 3rd generation PCR technology, named digital PCR, has developed for directly quantifying and clonally amplifying nucleic acids. This broad new patent is central to the use of nucleic acid binding compounds to inactivate pathogens in red blood cells. He also explored the many theoretical possibilities by which short nucleic acid sequences might code for the 20 amino acids. The enzymes digest the proteins and nucleic acids in the prey, releasing amino acids and phosphate ions, which the plant absorbs. The agreement between the companies expands on an earlier collaboration to create a new form of nucleic acid tests. It is classified into PCR, sequencing, northern blotting, southern blotting, molecular cloning, and other nucleic acid applications. Reductase nucleic acids and their encoded polypeptide were isolated and identified. Read about new biotechnology techniques, such as nucleic acid probes and other gene-based tools, which are providing faster and more accurate ways to detect and identify fish and shellfish disease agents. Suppose you want to make a nucleic acid vaccine against malaria. Human pharmacodynamic studies shall address the expression and function of the nucleic acid sequence following administration of the gene therapy medicinal product. Show More Sentences This means responses can be detected well in advance of standard ELISA-based systems, and even before nucleic acid testing can be used effectively. The advent of microminiaturization has presented new challenges for nucleic acid assays. This causes the formation of dimers in the base pairs of nucleic acids, particularly adjacent thymine base pairs. The nucleoprotein structure defined by the nucleic acid and the internal proteins is called nucleoid and the group nucleoid and capsid constitute a functional unity which is called nucleocapsid. Development of biodegradable and biocompatible non-viral vectors with intrinsical multifunctional properties such as bioimaging ability for highly efficient nucleic acids delivery still remains a challenge. She reported that nucleic acid measurement is still an immature and rapidly evolving technology, and emphasized that issues of accuracy are just as significant for qualitative DNA analysis as for quantitative DNA analysis. Particular challenges for metrology included the measurement of nucleic acid, where the sequence of base pairs in the acid has to be measured as well as the amount of material present. Two complementary nucleic acid-based methods were used to evaluate population changes relative to substrate production and use in these systems. Use of avidin or streptavidin or a derivative thereof as an interference-eliminating agent to avoid unspecific interactions in immunoassays or nucleic acid assays. Rapid identification of Staphylococcus aureus directly from blood cultures by fluorescence in-situ hybridization with peptide nucleic acid probes. Synthetic nucleic acids are used in the analysis of nucleic acid samples with unknown sequences and in virtually every genomic and genetic analysis technique. As with HIV, this low rate has been attributed to the ability to screen for both antibodies as well as viral RNA nucleic acid testing in donor blood. In addition to RNA and DNA, many artificial nucleic acid analogues have been created to study the properties of nucleic acids, or for use in biotechnology. Bioinformatics involves the development of techniques to store, data mine, search and manipulate biological data, including DNA nucleic acid sequence data. Locked Nucleci Acid probes are conformationally restricted nucleic acid analogs that provide enhanced affinity and discrimination as compared to DNA probes. Plants need nitrogen for protein synthesis, calcium for cell wall stiffening, phosphate for nucleic acid synthesis, and iron for chlorophyll synthesis. The invention also provides a transgenic seed plant, such as an angiosperm or gymnosperm, that contains a recombinant nucleic acid molecule of the invention. The combination of this test, and Bayer's current line of VERSANT HIV and HCV viral nucleic acid tests, delivers on Bayer's strategy to become a leader in NAD assay virology. The nucleic acids released using Pressure Cycling Technology will be evaluated for use in state-of-the-art amplification-based nucleic acid tests. But what about coenzyme Q10, superoxide dismutase, tyrosine, germanium, ginseng, quercetin, carnitine, and dozens of herbs, glandular extracts, amino acids, and nucleic acids? Show More Sentences The pyrimidine bases are the part of the nucleic acids, and therefore, both natural pyrimidines and pyrimidine derivatives have diverse effects on the body. Fodor is credited with developing high-density oligonucleotide arrays using photolithographic fabrication, parallel synthesis and solid phase synthesis of nucleic acids. Radical and radical ion reactivity in nucleic acid chemistry. For more than 40 years, researchers had known that RNA, a single-stranded nucleic acid, carries instructions from a gene to the cell's protein-making machinery. University of Kentucky has patented novel isolated nucleic acids encoding antigenic proteins derived from Sarcocystis neurona, or unique fragments thereof. After brief incubation with SYTOX Green stain, the nucleic acids of dead cells fluoresce bright green when excited with the 488-nm spectral line of the argon-ion laser. Examples from Classical Literature We have found substantial evidence which demonstrates that there is no interconversion of the two types of nucleic acid. Of the four basic components on the right, thymine occurs in the nucleic acid from the thymus gland. Adenine and guanine are constituents of all nucleic acids and, hence, are found in all plant and animal tissues. Solutions of nucleic acids are optically active, probably because of the carbohydrate constituents. Yeast is rich in nucleic acid, but this has not found any special applications. With this change in solute concentration can come shifts in pH, impacting nucleic acid strands passing through the liquid zones. A mixture containing nucleic acid and a transition metal enhancer is exposed to cells. Sequence logo analysis can find motifs in potentially related nucleic acid or protein sequences. The synthesis of both types of nucleic acid are independent of each other. Find more words! 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What is the adjective for nucleic? What is the noun for nucleic? Use our Sentence Generator Nearby Words nuclei nucleator nucleation nucleating nucleated nucleate nucleic acid nucleic acids nuclein nucleocapsid nucleoid nucleolar 7-letter Words Starting With n nu nuc nucl nucle nuclei