| Objective: Evaluation and management of patients with multiple maternal antibody isoimmunization is unclear. |
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| Management of fetal red blood cell isoimmunization requires a prediction of fetal anemia. |
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| Only three patients were born after prophylaxis against maternal isoimmunization had become common practice. |
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| Conclusions: The presence of anti-D appears to be the most significant factor guiding the course of isoimmunization with multiple antibodies. |
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| Study showed that severe hemolytic anemia after childbirth was due to isoimmunization caused by an irregular antibody. |
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| All white women showed a higher risk for cardiac conditions and isoimmunization, whereas older white women also demonstrated an increased risk for herpes infection and multiple gestation. |
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| The purpose of this study was to review the clinical outcomes of anti-D isoimmunization in a series of women who typed Rh positive or Rh weak positive. |
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| Isoimmunization should be ruled out, and consideration of karyotyping should be discussed. |
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