How to use endothelial in a sentence

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Sentence Examples Microscopic examination revealed the cysts were of varying size and shape and were lined by thin, attenuated endothelial cells. Pulmonary endothelial cells serve as gatekeepers to trafficking inflammatory and immune cells. Arterial and venous endothelial cells are molecularly distinct from the earliest stages of angiogenesis. The use of atomic force microscopy has recently allowed measurement of the endothelial surface topography in vitro for the first time. Can prolonged administration of endothelial antiapoptotic agents influence the growth of malignancies? By implanting the bone marrow mononuclear cells, we deliver endothelial progenitor cells and vascular growth factors at the same time. Interestingly, these receptors have been recently identified in human lung tissues and cultured human lung microvascular endothelial cells. These authors found ultrastructural evidence of altered endothelial and smooth muscle cells within chorionic vessels exhibiting HEV-like lesions. The integrity of the endothelial cell layer is also controlled by the tethering of the cells to the extracellular matrix through integrins. Bovine aortic endothelial cells were cultured in complete growth medium as described previously. In the kidney, the glomeruli show thickened capillary walls and endothelial swelling. These events contribute to leukocyte diapedesis across the endothelial monolayer and tissue inflammation. The tissue can be used for research and possibly for new forms of deep endothelial corneal transplant. The cornea is kept transparent by the continuous removal of fluid by the endothelial cells. They show a distinct so-called adventitia capillaris, a thin collagenous membrane, surrounding the endothelial tube. The dose of statins requires modification to attain LDL cholesterol levels that favorably effect endothelial function. This was further confirmed by the finding of a decrease in the number of endothelial cells in the lung. The endothelial responses to circumferential vascular stretch are poorly defined. Disturbances of normal endothelial function are strongly implicated in the pathogenesis of atherosclerosis and autoimmune vascular diseases. The staining was predominantly located in endothelial and perivascular cells within the tumors. Show More Sentences Other areas were densely cellular with a lobular infiltrate of plump endothelial cells surrounding small capillaries. It is unknown whether lowering plasma homocysteine levels with folic acid and cobalamin improves coronary endothelial function in patients. Aspirin also reduces endothelial cell production of prostacyclin, an inhibitor of platelet aggregation and a vasodilator. These connections occur through apertures in the basal laminae of both endothelial and epithelial cells. For all these cases, hepatocytes were more immunoreactive than endothelial cells and leukocytes. The origin of these endothelial cells, which play a vital role in the body's circulatory system and internal organs, had been uncertain. In the vertebrate vascular system, shear stress exerted by blood flow has substantial effects on endothelial cell morphology and behavior. Many biochemical substances, principally of placental and endothelial origin, increase in pre-eclampsia. They consist of thin sheets of collagen and smooth muscle with an endothelial covering. One potential concern raised by the study was the loss of endothelial cells in the corneas of patients who received the implants. This consisted of proliferating vascular channels lined by atypical endothelial cells, which in turn were surrounded by spindle-shaped cells. Myogenic cells that do not carry endothelial markers in situ also start to produce them when cultured in endothelium growth medium. There are many adhesion molecules that are expressed in response to ischemia in endothelial cells. This basal lamina underlines all epithelial and endothelial tissues, and separates these from other types of tissue. An evaluation of FVIII expression in phenotypically distinct endothelial cells. Our lab continues to investigate neuronal death and it's relationship to endothelial activation after cerebral ischemic-reperfusion injury. Eosinophillic intranuclear inclusions of Cowdry type A are found in oligodendrocyte, astrocytes, occasional neurons, ependymal cells, endothelial cells, and schwann cells. In a fenestrated capillary wall, holes as large as 100 nanometres are found in the endothelial cells. In the new endothelium, the EPCs have to differentiate into mature endothelial cells if they are to become functional. Iridocorneal endothelial syndrome is a syndrome in which there is a character abnormality of the corneal endothelium. Show More Sentences However, mechanisms of endothelial injury and death are not all that need to be considered when making a prognosis. This barrier is made of lines of endothelial cells that normally prevent lymphocytes from squeezing into the brain tissue. The effectiveness of intravitreal injection of antivascular endothelial growth factor antibodies as treatment for ROP is under study. Endothelial cell stretch has been examined previously using innovative in vitro systems applying mechanical stretch of confluent endothelial cell monolayers. The endothelial tube everywhere remains intact and continuous. All this indicates that vascular endothelial growth factor may contribute to the establishment, progression, and regression of prostate neoplasia. Indeed, triterpenoid saponins with an acyl side chain have been shown to increase membrane permeability of endothelial cells, whereas those lacking the side chain did not. Unfortunately, the absence of endothelial cells at the luminal surface of prosthetic vascular grafts potentiates thrombosis and neointimal hyperplasia. Leukocytes may adhere, transmigrate, release proteases, cause additional endothelial injury, and lead to the development of inflammatory changes in the vessel wall. The nodes contain lymphocytes, which enter from the bloodstream via specialized vessels called the high endothelial venules. Prediction of fluid shear force distribution on the endothelial surface has been computed from topographical maps measured by atomic force microscopy. By in situ hybridization, MnSOD mRNA can be detected in arterioles, septal tips of alveolar ducts, endothelial cells, and in pleural mesothelium of hyperoxia-exposed rats. Aligned fluorescent endothelial cells on unweaved polyethylene terephthalate fibres. Thirdly, simvastatin inhibits endothelial cell apoptosis and preserves ischaemic vasculature, perhaps maintaining a competent vascular supply to the macula. In our lab we developed the antibody S-Endo 1, which recognises the antigen CD146 that is exposed on the surface of all endothelial cells. The high expression of zonula occludens was the characteristic of the confluent brain endothelial cell monolayers. The process of atherogenesis involves inflammation and endothelial dysfunction. Venous valves are seen as bicuspid folds derived from the wall and lined by endothelial cells. Coronary epicardial and arteriolar endothelial function was tested in vitro. Repetitive episodes of coronary artery spasm and paroxysms of hypertension may result in endothelial damage, coronary artery dissection, and acceleration of atherosclerosis. Show More Sentences On their inside, the tubes entrap endothelial cells, a type of cell that naturally forms blood vessels. Plasma ADM is mainly derived from vascular endothelial cells, smooth muscle cells, and adventitial fibroblasts. Further, it could be shown that EMPs stimulate vascularization and increase the number of endothelial cells. Immunohistologic demonstration of endothelial disruption in acute atherosis in pre-eclampsia. Parasites that infect macrophages or endothelial cells can develop into megaloschizonts, generating more merozoites. Thus, endothelial expression of AQP1 characterizes the atheroprotected, non-inflamed vessel wall. The cellular hexagonality could also be identified, suggesting intact corneal endothelial morphology. Chlamydia pneumoniae infects vascular and endothelial cells and has been identified in and grown from atheromas. Methamphetamine induces AP-1 and NF-kappaB binding and transactivation in human brain endothelial cells. The venules consist of an endothelial tube supported by a small amount of collagenous tissue and, in the larger venules, by a few smooth muscle fibres as well. These factors are specific for endothelial cells and inhibit their growth to a variety of angiogenic growth factors secreted from human tumors. We have isolated two novel single-domain antibodies that bind to antigens on the surface of brain endothelial cells and can transmigrate into the brain. Early effect of treatment with nebivolol and quinapril on endothelial function in patients with hypertension. When single late cells are transferred to fresh cultures, they divide rapidly and grow to confluence, displaying the typical cobblestone appearance of endothelial cells. Effect of sulfinpyrazone on homocysteine-induced endothelial injury and arteriosclerosis in baboons. Nonsteroidal anti-inflammatory drugs may also impair endothelial function as well as increase sodium absorption in the kidneys. When the concentration of growth factors in the culture medium is reduced the cloned cells will differentiate into endothelial cells as well as smooth and striated muscle cells. The autografts tended to become malaligned in control animals, whereas the tracheal architecture was preserved in rabbits treated with vascular endothelial growth factor. Upon maturation, bone marrow neutrophils are released into the circulation where they marginate on inflamed blood vessel endothelial cells and migrate through them into the area of infection. The present study was designed to elucidate the role of endothelial dysfunction in thrombogenesis associated with nonvalvular atrial fibrillation. Show More Sentences Here, we used recombinant organ culture experiments to show that immigrant cells are endothelial, not peritubular myoid or other interstitial cells. Eicosapentaenoic acid improves endothelial function in hypertriglyceridemic subjects despite increased lipid oxidability. However, if EPC mobilization from the bone marrow and recruitment to sites of vascular injury are impaired, vascular homeostasis may be deviated towards endothelial dysfunction and susceptibility to atherogenesis. Glyoxal and methylglyoxal trigger distinct signals for MAP family kinases and caspase activation in human endothelial cells. However, varicocele is mainly a vascular pathology with endothelial dysfunction as the main pathogenetic factor. The active enzyme involved in the fibrinolytic process is plasmin, which is formed from its precursor, plasminogen, under the influence of an activating factor released from endothelial cells. Dr. Ganz researched the molecular mechanisms of action of clotting and fibrinolytic factors and their interaction with platelets and human endothelial cells. The lac-z gene product could be detected in endothelial cells only in certain blood vessels in the brain and retina, as well as in endocardial cells that invade the cardiac jelly in the embryonic heart. Desmopressin is a synthetic form of antidiuretic hormone which causes the release of factor VIII and von Willebrand factor from the endothelial cell storage sites. Protein C, a vitamin K-dependent protein, is a zymogen that requires vitamin K for its activation by thrombin complexed to thrombomodulin, a protein on the endothelial cell membrane. Aneurysmal bone cysts have no endothelial lining and, therefore, should be considered as pseudocysts rather than cysts. We hypothesised that statins might also be activating endothelial genes that are athero-protective, and that are controlled endogenously by the transcription factor KLF2 when it is activated by haemodynamic forces. Distinct effects of naringenin and hesperetin on nitric oxide production from endothelial cells. With this laboratory version of the blood-brain-barrier she can test if messages passing between endothelial cells and T cells increase the BBB leakiness. The lining cells are positive for both endothelial and histiocytic markers. Furthermore, indirect evidence is accumulating to suggest that the pleiotropic, antiinflammatory, and endothelial protective effects of statins may be an important determinant of their overall therapeutic benefit. It is a single cell layer thick and is composed of squamous endothelial cells. Posttranscriptional stimulation of endothelial cell matrix metalloproteinases 2 and 1 by endothelioma cells. In slices of aorta used as a sprouting assay, the sprouting tips of endothelial cells moved away from a source of netrin and filopodia in the mouse retina and hindbrain retracted after netrin was injected. Stimulation with BMP4, a mesoderm inductor, allows to reduce the time to visualize an immature endothelial cells population, which, when cultivated, gain functionnal endothelial cells functions. Show More Sentences If the endothelial cells become damaged, however, plaque can build up. This technique can be applied to other fish tissues such as liver, spleen and heart providing a reasonable quantity of endothelial cells, leucocytes or lymphocytes can be deposited on the slide. The C4d thus generated binds covalently to endothelial cell surfaces and the extra cellular matrix components of vascular basement membranes. Difference in uptake and toxicity of trivalent and pentavalent inorganic arsenic in rate heart microvessel endothelial cells. This protective effect requires mitogenesis, and endothelial progenitor cell differentiation, proliferation and migration. Ischemic diseases HFG can stimulate the migration, proliferation and neovascularization of vascular endothelial cells. Inflammatory status and endothelial dysfunction may also impair the expression of brain-derived neurotropic factor. Leukocytoclasis, endothelial swelling, and subepidermal edema are frequently noted, but vasculitis is not present. Tie2 is a receptor tyrosine kinase expressed on vascular endothelial cells, which plays a key role in stabilizing blood vessels. Effect of Vaccinum myrtillus and its polyphenols on angiotensin-converting enzyme activity in human endothelial cells. Vascular endothelial growth factor secretion has also been observed in human tissue-engineered vessels using smooth muscle cells. Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells. Previous experiments have shown that tumstatin was effective at blocking endothelial cell growth in gliomas. Resveratrol, a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide synthase. Influence of 3, 4', 5-trihydroxystibene-3-mono-D-glucoside on vascular endothelial epoprostenol and platelet aggregation. Vascular endothelial growth factor-induced osteopontin expression mediates vascular inflammation and neointima formation via Flt-1 in adventitial fibroblasts. A key mediator in angiogenesis is vascular endothelial growth factor, as it stimulates endothelial cell proliferation and migration and increases vascular permeability. The pair also found that the 23-nanometer semispherical surface yielded 15 percent more healthy endothelial breast cells compared to normal surface after one day of lab tests. Arterial stiffness and endothelial dysfunction can be determined using pulse wave velocity, and, brachial and aortic augmentation index, respectively. EyeTech has received worldwide rights to all therapeutic uses of Gilead's proprietary aptamer NX 1838, an inhibitor of vascular endothelial growth factor. Show More Sentences The people with ALS were nearly twice as likely to have one of two variant forms of a gene for the protein called vascular endothelial growth factor. With regard to elucidating the antithrombogenicity of the endothelial cells, we performed additional staining with anti-thrombomodulin and anti-tissue factor. Intraoperative application of mitomycin C is very effective but there are concerns as to the long-term effects of this treatment on keratocyte and endothelial cell density. Establishment of permanent human endothelial cells achieved by transfection with SV40 large T antigen that retain typical phenotypical and functional characteristics. Tumor necrosis factor-alpha production, inducible nitric oxide synthase, and endothelial nitric oxide synthase protein expression were analyzed in visceral adipose tissue. Artichoke juice improves endothelial function in hyperlipemia. The endothelial cells are enlarged and appear epithelioid or histiocytic. Furthermore, elevated TG levels may influence mechanisms associated with the development of CVD, including thrombogenesis, endothelial dysfunction, and oxidative stress. The bacterial endotoxins consume antithrombin III as well as proteins C and S, thus, disturbing the anticoagulant and procoagulant endothelial cell activity. Cell rolling on endothelial cells is mediated by E-selectin, a cell adhesion molecule that is also responsible for recruiting leukocytes as part of the inflammatory response. Prostate-specific membrane antigen presents a novel endothelial target. Leukocytes are attracted to the injury site by chemotactic proteins known as chemokines, which are secreted by endothelial cells of the blood vessels. Secreted monocytic mir-150 enhances targeted endothelial cell migration. Expression and localization of the vascular endothelial growth factor and changes of microvessel density during hair follicle development of liaoning cashmere goats. Characteristics are particularly evident in the dermal microvasculature, including endothelial swelling and concentric thickening of the vascular basement membrane. Temporary endothelial gaps in the extending tips of growing metaphyseal vessels were suggested as the location of bacterial passage from the blood stream into the metaphysis. This still-unnamed drug is a thiazole derivative that inhibits superoxide production, cytokine production, and endothelial adhesion of neutrophils and monocytes. Examples from Classical Literature Some of the endothelial cells lining the coelom are ciliated, the cilia keeping the corpusculated fluid contents in movement. Predominance of endothelial cells, few cells of any kind being present, indicates a transudate. Arteriography may assess arterial stiffness, endothelial dysfunction and arterial age. Find more words! 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What is the adjective for endothelial? What is the noun for endothelial? Use our Sentence Generator Nearby Words endosymbiotic theory endosymbiotic endosymbiosis endosymbionts endosymbiont endosulfan endothelioma endothelium endotherm endothermal endothermic endothermic reaction 11-letter Words Starting With e en end endo endot endoth endothe endothel endotheli endothelia