| The percentage of HDL-c increase was 37 percent in the VIRAMUNE regimens compared to 24 percent in the efavirenz regimen. |
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| Merck backed down when a Brazilian government laboratory showed it could make efavirenz cheaply, and thus that Mr Serra's threat was no bluff. |
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| The optimal dose of indinavir, when given in combination with efavirenz is not known. |
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| Meanwhile, a compulsory license was issued the first time in Brazil in 2007, for the drug efavirenz, commercialized by Merck and used by 80 000 people in the country. |
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| In generic form, it costs one-eighth as much as efavirenz, the most closely related drug. |
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| These were followed by indinavir with ritonavir, saquinavir with efavirenz, and saquinavir with ritonavir. |
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| A month earlier, Merck, an American company, had agreed to cut sharply the price it charges Brazil for efavirenz, an AIDS treatment, after Mr Serra had threatened to break its patent. |
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| The Viramune® once-daily arm had a significantly higher incidence of grade 3 or 4 liver associated laboratory abnormalities compared to the efavirenz arm. |
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| In March 2008, Bristol Myers Squibb announced that the company would stop the distribution of the 100mg pediatric capsule formulation of efavirenz in France. |
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| The ongoing study continues to test whether once-daily efavirenz, with abacavir and lamivudine, could replace the common twice-daily regimen. |
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| Myelomeningocele in a child with intrauterine exposure to efavirenz. |
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| Efavirenz should not be used during pregnancy because of possible teratogenicity, and the potential for oncogenic toxicity is unknown. |
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| Efavirenz is marketed by Bristol-Myers Squibb under the tradename SUSTIVA in the United States, Canada and six European countries. |
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