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What is the opposite of most irrelevantly?

Need antonyms for most irrelevantly? Here's a list of opposite words from our thesaurus that you can use instead.

Adverb
Opposite of superlative for in an irrelevant manner
Adverb
Opposite of superlative for in a sufficiently great or important way as to be worthy of attention
“My argument is slightly, but not insignificantly, different.”
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