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What is a vicissitude?

What is a vicissitude? Here are some definitions.

Noun
  1. Regular change or succession from one thing to another, or one part of a cycle to the next; alternation; mutual succession; interchange.
  2. (plural) A change, especially in one's life or fortunes.
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Examples
The state's once-favored son — a bridge in Omaha bears his name — now finds himself recast as a carpetbagger, navigating a landscape both familiar and foreign after 12 years of political vicissitude.
Many others, however, accepted the shutdown as yet another vicissitude of urban life.
We have to accept the vicissitude sequent on a violated treaty.
Every vicissitude that life can throw at Rembrandt – each pouch and jowl, every newly acquired line – calls for an artistic answer.
Time, the continual vicissitude of circumstances, and the invariable inopportunity of death, render it impossible.
Carolina Bagnarol, a former business manager for the rock group Journey who is no stranger to vicissitude, is skeptical.

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