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What does severe mean?

Looking for the meaning or definition of the word severe? Here's what it means.

Adjective
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The duodenal mucosa showed severe villous atrophy but no subepithelial collagen deposition.
For example, nondisclosure could be considered reasonable in the case of a patient with severe depression who was at risk of attempting suicide.
Clinical clues to possible hyperandrogenism in women include dysmenorrhea, virilization, and severe acne.
Patients who are immunocompromised or who have undergone a splenectomy are at increased risk for severe complications.
The splenic artery was encased by tumor, although there was no intraluminal invasion, and the artery showed severe calcific atherosclerosis.
These lights enhance your visibility especially in severe weather conditions.

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