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What is refractoriness?

What is refractoriness? Here are some definitions.

Noun
  1. The quality of being refractory.
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Examples
The great Potter is not to be blamed because of the refractoriness of the clay.
And he only gave way after Bartek's refractoriness also had been softened by unusual eloquence on Porankiewicz's part.
Genes conferring resistance to insecticides are more accessible to genetic study than genes involved in parasite refractoriness.
Patients in the study had already demonstrated refractoriness to physical therapy.
Felodipine in therapeutic doses has no effect on conduction in the conducting system of the heart and no effect on the A-V nodal refractoriness.
This refractoriness varies in every species of animal in its relation to every form of germ.

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