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What is refractoriness?

What is refractoriness? Here are some definitions.

Noun
  1. The quality of being refractory.
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Examples
I considered them, therefore, as beings influenced by the most deplorable obduracy and refractoriness of spirit.
The great Potter is not to be blamed because of the refractoriness of the clay.
He is willing to hope you to be all obedience, and would prevent all incitements to refractoriness.
Genes conferring resistance to insecticides are more accessible to genetic study than genes involved in parasite refractoriness.
Since all resistance is useless, I lay down my arms although after relapses into refractoriness.
This refractoriness varies in every species of animal in its relation to every form of germ.

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