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What is refractoriness?

What is refractoriness? Here are some definitions.

Noun
  1. The quality of being refractory.
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Examples
Patients in the study had already demonstrated refractoriness to physical therapy.
Platelet alloantibodies are responsible for neonatal alloimmune thrombocytopenia and platelet refractoriness.
He is willing to hope you to be all obedience, and would prevent all incitements to refractoriness.
Felodipine in therapeutic doses has no effect on conduction in the conducting system of the heart and no effect on the A-V nodal refractoriness.
I considered them, therefore, as beings influenced by the most deplorable obduracy and refractoriness of spirit.
This refractoriness varies in every species of animal in its relation to every form of germ.

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