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What does presynaptically mean?

Looking for the meaning or definition of the word presynaptically? Here's what it means.

Adverb
  1. In a presynaptic manner
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Examples
We used PPF to test the hypothesis that TDE, galanthamine and ACh reduce synaptic responses by presynaptically depressing glutamatergic release.
Cocaine blocks the reuptake of catecholamines presynaptically.
We find that the occurrence of glia postsynaptically is strikingly higher than presynaptically, in both types of synapses.
Pregabalin works presynaptically on overactive calcium channels and can reduce the symptoms of neuropathic pain.
The neurotoxins act presynaptically, initially releasing acetylcholine, followed by an interference with or blockade of its release.
Glutamate is released presynaptically and binds to a postsynaptic receptor gating a cation-selective channel, thus depolarizing the post-synaptic cell.

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