In this work, the molar concentrations of the oligonucleotide duplexes are related to the double-stranded molecules 15-bp long. |
The drugs in the latter complexes are covalently connected by a peptide linker, whereas those associated with the oligonucleotide duplexes are chemically independent species. |
One important application is gene therapy, where it is necessary to deliver a gene or a synthetic oligonucleotide into the cell. |
The bands containing labeled oligonucleotide were identified by visual inspection and ultraviolet shadowing. |
The quaternary nitrogen atom in lycobetaine plays an important role in the formation of hydrogen bonds between the compound and the oligonucleotide. |
The latter is conjugated to primer oligonucleotides that are pre-annealed to a complementary circular oligonucleotide. |