| Both neuritic plaques and neurofibrillary tangles, which also may be found in smaller amounts in the brains of healthy elderly persons, are thought to interfere in some way with normal cellular functioning. |
| Aluminum has been shown to coexist with silicon in an aluminosilicate form in the amy-loid core of senile plaques and neurofibrillary tangles of AD brains. |
| It is the first drug capable of dissolving tau protein fibres and preventing the formation of neurofibrillary tangles. |
| The presence of neuritic plaques and neurofibrillary tangles in the brain are used to diagnose Alzheimer disease in autopsy. |
| Two other characteristic tissue lesions found in the cerebral cortex of patients with Alzheimer's disease are neuritic plaques and neurofibrillary tangles. |
| Aluminum has been found in the neurofibrillary tangles in brains of AD patients examined post-mortem, but whether it is a cause or a result of the condition is unknown. |
