| Concomitant thiazide diuretic use may attenuate any effect that losartan may have on serum potassium. |
| Both biliary and urinary excretion contribute substantially to the elimination of losartan and its metabolites. |
| The terminal half-life of losartan itself is about 2 hours, and that of the active metabolite, about 6-9 hours. |
| Neither losartan nor the active metabolite can be removed by hemodialysis. |
| Photosensitivity has been reported with both losartan potassium and hydrochlorothiazide. |
| Much of the global growth was due to strong performance by the recent launches of losartan and metaxalone and the continued performance from tacrolimus. |
