| Cytokines produced by activated mononuclear cells and keratinocytes probably contribute to local cell death, fever and malaise. |
| Ploidy analysis shows that the keratinocytes in the large cell acanthoma are frequently aneuploid. |
| The overlying epidermal layer consists of living human keratinocytes organized in a fully differentiated, stratified epidermis with an outer stratum corneum. |
| They connect with the developing keratinocytes through intercellular connections, or desmosomal junctions. |
| Occasionally, the reactive keratinocytes may show individual keratinization and nonatypical mitosis. |
| Healing is expected within two weeks by regeneration of epidermis from keratinocytes within sweat glands and hair follicles. |
