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What does depravation mean?

Looking for the meaning or definition of the word depravation? Here's what it means.

Noun
  1. Detraction; depreciation. (Can we add an example for this sense?)
  2. The act of depraving, or making anything bad; the act of corrupting.
  3. The state of being depraved or degenerated; degeneracy; depravity.
  4. Change for the worse; deterioration; morbid perversion.
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From Kent to the north of Scotland, there are old mining communities living in depravation, at a huge social cost.
Anti-poverty strategies are focused on the physical aspects of depravation, rather than on the more intangible ones.
All I need is a 35-40 hour day and an immunity to sleep depravation and I'll perhaps be able to do it one day.
Stresses such as oxygen depravation, toxicity in the influent, or nutrient deficiencies will produce high BSI values.
They suspected before they began that sleep depravation, smoking, extra jobs and a social life all contributed to a lack of concentration.
He left fairly comfortable circumstances to sail 12,000 miles and suffered hardship and depravation.

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