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What is a chancre?

What is a chancre? Here are some definitions.

Noun
  1. (pathology) Skin lesion, sometimes associated with certain contagious diseases such as syphilis.
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In addition, the spirochetes can be viewed by examining fluid from the primary chancre or secondary lesions under the microscope.
In those not previously exposed to M. tuberculosis, miliary tuberculosis of the skin and tuberculosis chancre have been described.
Primary syphilis is most often associated with a single, painless chancre, although it can manifest in other ways.
The chancre may be so slight in colour as to go unnoticed, but the presence of spirochetes in the chancre serum is diagnostic for syphilis.
These tests normally become positive one to four weeks after the appearance of a primary chancre, approximately six weeks after infection.
The appearance of the soft chancre is followed by enlargement and inflammation of the regional lymph nodes.

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