| At first, an ulcer called a chancre is noticed in the mouth or on genital organs. |
| In those not previously exposed to M. tuberculosis, miliary tuberculosis of the skin and tuberculosis chancre have been described. |
| These tests normally become positive one to four weeks after the appearance of a primary chancre, approximately six weeks after infection. |
| This chancre may look like a pimple, blister, or open sore and usually appears in the genital area. |
| The appearance of the soft chancre is followed by enlargement and inflammation of the regional lymph nodes. |
| Primary syphilis is most often associated with a single, painless chancre, although it can manifest in other ways. |
