There was no good animal test to screen for the ataraxic effects, because the antihistamines made laboratory animals hyperexcitable, not calm. |
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Once this hyperexcitable state has been set up, it continues for some time without further input from the peripheral nerves. |
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It is believed that the brains of persons with migraine have hyperexcitable neurophysiological responses, with an inability to normally suppress the electrical response to certain visual and auditory stimuli. |
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We know that cells can become hyper-excitable because that occurs in epilepsy, and we have described how pain-producing cells can become hyperexcitable after inflammation or nerve damage. |
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