This control consists in the nullizygous plant, i.e., a non-transgenic sibling originating from a hemizygous plant. |
|
It was found that hemizygous disruption of the XRCC3 gene was sufficient to increase the point mutation frequency. |
|
Mendelian segregation ratios of 3:1 were obtained as expected for a single copy hemizygous trait for all above tests. |
|
The method would therefore be amenable to screening an X-linked dominant disorder with heterozygous females and hemizygous male patients. |
|