Superlative for significant in degree of importance or urgency
“Jon Snow felt that the White Walkers were a major issue that he and Daenerys had to address immediately.”
Superlative for noteworthy historically, or among one's peers
“Francis Bacon is regarded as one of the major painters of the 20th century.”
Superlative for complicated in nature
“He had to undergo major surgery, followed by months of rehabilitation.”
Superlative for arduous in nature
“This is a major undertaking that will literally take years to complete.”
Superlative for large in size, degree or amount
“This seems like a good strategy to make some major cash in a short space of time.”
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