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What is a ruination?

What is a ruination? Here are some definitions.

Noun
  1. The state of being ruined, a state of devastation or destruction.
  2. The act of ruining or wrecking.
  3. The cause of being ruined, destroyed or lost.
  4. A loss of reputation.
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Examples
In experiencing uncanniness, the ruination and questionability of life are encountered.
But he had his own path to ruination he was set upon, and my being around did nothing to deter him.
And it is David's well-meaning employment of Sheila as a secretary that leads to his ruination.
This relationship was unrealistic, and doomed from the outset, came between Wilde and his art, and became his ruination.
I suspect that the neglectful ruination of Havana has served a profoundly ideological purpose.
We could have stalled the ruination of thousands of small production units if we had paid heed to the plea of a level-playing field.

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